{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:14:41Z","timestamp":1780938881039,"version":"3.54.1"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>\n                    Among opioids, buprenorphine presents a favorable safety profile with a limited risk of respiratory depression. However, fatalities have been reported when buprenorphine is combined to a benzodiazepine. Potentiation of buprenorphine interaction with opioid receptors (ORs) with benzodiazepines, and\/or vice versa, is hypothesized to explain this drug-drug interaction (DDI). The mutual DDI between buprenorphine and benzodiazepines was investigated at the neuroreceptor level in nonhuman primates (n\u2009=\u20094 individuals) using brain PET imaging and kinetic modelling. The binding potential (BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) of benzodiazepine receptor (BzR) was assessed using\n                    <jats:sup>11<\/jats:sup>\n                    C-flumazenil PET imaging before and after administration of buprenorphine (0.2\u2009mg, i.v.). Moreover, the brain kinetics and receptor binding of buprenorphine were investigated in the same individuals using\n                    <jats:sup>11<\/jats:sup>\n                    C-buprenorphine PET imaging before and after administration of diazepam (10\u2009mg, i.v.). Outcome parameters were compared using a two-way ANOVA. Buprenorphine did not impact the plasma nor brain kinetics of\n                    <jats:sup>11<\/jats:sup>\n                    C-flumazenil.\n                    <jats:sup>11<\/jats:sup>\n                    C-flumazenil BP\n                    <jats:sub>ND<\/jats:sub>\n                    was unchanged following buprenorphine exposure, in any brain region (p\u2009&gt;\u20090.05). Similarly, diazepam did not impact the plasma or brain kinetics of\n                    <jats:sup>11<\/jats:sup>\n                    C-buprenorphine.\n                    <jats:sup>11<\/jats:sup>\n                    C-buprenorphine volume of distribution ( V\n                    <jats:sub>T<\/jats:sub>\n                    ) was unchanged following diazepam exposure, in any brain region (p\u2009&gt;\u20090.05). To conclude, our PET imaging findings do not support a neuropharmacokinetic or neuroreceptor-related mechanism of the buprenorphine\/benzodiazepine interaction.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231221040","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T22:43:50Z","timestamp":1702593830000},"page":"449-458","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain PET imaging using\n                    <sup>11<\/sup>\n                    C-flumazenil and\n                    <sup>11<\/sup>\n                    C-buprenorphine does not support the hypothesis of a mutual interaction between buprenorphine and benzodiazepines at the neuroreceptor level"],"prefix":"10.1177","volume":"44","author":[{"given":"Sylvain","family":"Auvity","sequence":"first","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Cit\u00e9, Inserm, UMRS-1144, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-3574","authenticated-orcid":false,"given":"Salvatore","family":"Cisternino","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Cit\u00e9, Inserm, UMRS-1144, Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Chevillard","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Cit\u00e9, Inserm, UMRS-1144, Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Soyer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d\u2019Imagerie Biom\u00e9dicale Multimodale (BioMaps), Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Bottlaender","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d\u2019Imagerie Biom\u00e9dicale Multimodale (BioMaps), Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Caill\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d\u2019Imagerie Biom\u00e9dicale Multimodale (BioMaps), Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"M\u00e9garbane","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Cit\u00e9, Inserm, UMRS-1144, Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"},{"name":"R\u00e9animation M\u00e9dicale et Toxicologique, H\u00f4pital Lariboisi\u00e8re, F\u00e9d\u00e9ration de Toxicologie (APHP), 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