{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:41:32Z","timestamp":1793295692563,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Preterm birth is associated with cerebrovascular development disruption and can induce white matter injuries (WMI). Transfontanellar ultrasound Doppler is the most widely used clinical imaging technique to monitor neonatal cerebral vascularisation and haemodynamics based on vascular indexes such as the resistivity index (RI); however, it has poor predictive value for brain damage. Indeed, these RI measurements are currently limited to large vessels, leading to a very limited probing of the brain\u2019s vascularisation, which may hinder prognosis. Here we show that ultrafast Doppler imaging (UfD) enables simultaneous quantification, in the whole field of view, of the local RI and vessel diameter, even in small vessels. Combining both pieces of information, we defined two new comprehensive resistivity parameters of the vascular trees. First, we showed that our technique is more sensitive in the early characterisation of the RI modifications between term and preterm neonates and for the first time we could show that the RI depends both on the vessel diameter and vascular territory. We then showed that our parameters can be used for early prediction of WMI. Our results demonstrate the potential of UfD to provide new biomarkers and pave the way for continuous monitoring of neonatal brain resistivity.<\/jats:p>","DOI":"10.1177\/0271678x241232197","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T19:02:40Z","timestamp":1707591760000},"page":"1577-1590","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-8862","authenticated-orcid":false,"given":"Flora","family":"Faure","sequence":"first","affiliation":[{"name":"Physics for Medicine, INSERM U1273, CNRS, ESPCI, PSL Research University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-716X","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Baranger","sequence":"additional","affiliation":[{"name":"Physics for Medicine, INSERM U1273, CNRS, ESPCI, PSL Research University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Alison","sequence":"additional","affiliation":[{"name":"Department of Radiology, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 Children\u2019s Hospital, University Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Boutillier","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 Children\u2019s Hospital, University Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Fr\u00e9rot","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 Children\u2019s Hospital, University Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 Children\u2019s Hospital, University Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Planchette","sequence":"additional","affiliation":[{"name":"Department of Radiology, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 Children\u2019s Hospital, University Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Prigent","sequence":"additional","affiliation":[{"name":"Department of Radiology, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 Children\u2019s Hospital, University Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micka\u00ebl","family":"Tanter","sequence":"additional","affiliation":[{"name":"Physics for Medicine, INSERM U1273, CNRS, ESPCI, PSL Research University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Baud","sequence":"additional","affiliation":[{"name":"Department of Pediatric, University Hospital of Geneva, University of Geneva, Geneva, Switzerland. O.B. is also with INSERM U1141, Robert Debr\u00e9 Children\u2019s Hospital, University Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Biran","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 Children\u2019s Hospital, University Paris Cit\u00e9, Paris, France"},{"name":"I2D2, INSERM U1141, University Paris Cit\u00e9 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Demen\u00e9","sequence":"additional","affiliation":[{"name":"Physics for Medicine, INSERM U1273, CNRS, ESPCI, PSL Research University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"bibr1-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70294-1"},{"key":"bibr2-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3351"},{"key":"bibr3-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200111000-00003"},{"key":"bibr4-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003606"},{"key":"bibr5-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1159\/000357553"},{"key":"bibr6-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56724-7"},{"key":"bibr7-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00487.2013"},{"key":"bibr8-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102756"},{"key":"bibr9-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307919"},{"key":"bibr10-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0202-6"},{"key":"bibr11-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2009.1067"},{"key":"bibr12-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2013.2592"},{"key":"bibr13-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2011.1780"},{"key":"bibr14-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.49"},{"key":"bibr15-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.227"},{"key":"bibr16-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34307-9"},{"key":"bibr17-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.11152\/mu-1901"},{"key":"bibr18-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2428634"},{"key":"bibr19-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2018.2789499"},{"key":"bibr20-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.15837\/ijccc.2013.2.308"},{"key":"bibr21-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.03.005"},{"key":"bibr22-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2550102"},{"key":"bibr23-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1177\/016173468600800201"},{"key":"bibr24-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2014.3049"},{"key":"bibr25-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-016-3615-x"},{"key":"bibr26-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.11"},{"key":"bibr27-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.1.2648468"},{"key":"bibr28-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2009000300017"},{"key":"bibr29-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30159-3"},{"key":"bibr30-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0535-0"},{"key":"bibr31-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13663"},{"key":"bibr32-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14330-z"},{"key":"bibr33-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1007\/BF02387890"},{"key":"bibr34-0271678X241232197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2005.12.007"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X241232197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X241232197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X241232197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:14:55Z","timestamp":1777493695000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X241232197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,10]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/0271678X241232197"],"URL":"https:\/\/doi.org\/10.1177\/0271678x241232197","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,10]]}}}