{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:06Z","timestamp":1787018766890,"version":"build-2736575974"},"reference-count":98,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson\u2019s disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure cerebrovascular reactivity (CVR) in response to hypercapnia in 26 PD patients and 16 healthy controls (HC), and aimed to find a multivariate pattern specific to PD. Whole-brain maps of CVR amplitude (i.e., magnitude of response to CO\n                    <jats:sub>2<\/jats:sub>\n                    ) and latency (i.e., time to reach maximum amplitude) were computed, which were further analyzed using scaled sub-profile model principal component analysis (SSM-PCA) with leave-one-out cross-validation. A meaningful pattern based on CVR latency was identified, which was named the PD CVR pattern (PD-CVRP). This pattern was characterized by relatively increased latency in basal ganglia, sensorimotor cortex, supplementary motor area, thalamus and visual cortex, as well as decreased latency in the cerebral white matter, relative to HC. There were no significant associations with clinical measures, though sample size may have limited our ability to detect significant associations. In summary, the PD-CVRP highlights the importance of cerebrovascular dysfunction in PD, and may be a potential biomarker for future clinical research and practice.\n                  <\/jats:p>","DOI":"10.1177\/0271678x241241895","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:51:31Z","timestamp":1712317891000},"page":"1774-1786","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Parkinson\u2019s disease cerebrovascular reactivity pattern: A feasibility study"],"prefix":"10.1177","volume":"44","author":[{"given":"Harm Jan","family":"van der Horn","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei A","family":"Vakhtin","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience, The Mind 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