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We provide commentary on the physiologic underpinnings and assumptions of NIRS and the COx, potential confounds in the context of HIBI, and the implications for the assessment of cerebral autoregulation.<\/jats:p>","DOI":"10.1177\/0271678x241245488","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T15:39:14Z","timestamp":1712849954000},"page":"1057-1060","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Shining a light on cerebral autoregulation: Are we anywhere near the truth?"],"prefix":"10.1177","volume":"44","author":[{"given":"Jordan D","family":"Bird","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Vancouver General Hospital"},{"name":"Collaborative Entity for REsearching BRain Ischemia (CEREBRI), University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"MacLeod","sequence":"additional","affiliation":[{"name":"Human Pharmacology &amp; 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