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Induced pluripotent stem cells (iPSCs) offer a promising source for cell replacement therapies, but their practical application faces challenges due to poor survival and integration after transplantation. Park et\u00a0al. propose a novel therapeutic strategy involving the co-transplantation of regulatory T cells (Tregs) and iPSC-derived dopamine neurons. This combined approach enhances the survival of transplanted cells and protects against neuroinflammation-induced damage. In PD animal models, the co-transplantation approach significantly suppressed the host immune response, resulting in improved behavioral recovery. Additionally, Tregs demonstrate acute neuroprotection and contribute to delayed neuro-restoration in ischemic stroke. This combined approach of cell therapy with immunomodulation offers a promising avenue for advancing our understanding of neurological diseases and promoting the development of novel treatments.<\/jats:p>","DOI":"10.1177\/0271678x241245633","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T06:53:24Z","timestamp":1713336804000},"page":"1246-1249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Co-transplantation of autologous treg cells: A groundbreaking cell therapy for brain diseases"],"prefix":"10.1177","volume":"44","author":[{"given":"Yue","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueman","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-9914","authenticated-orcid":false,"given":"Peiying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"bibr1-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0257-7"},{"key":"bibr2-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06300-4"},{"key":"bibr3-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.01.007"},{"key":"bibr4-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.036072"},{"key":"bibr5-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-022-00975-z"},{"key":"bibr6-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23815"},{"key":"bibr7-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.09.014"},{"key":"bibr8-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.628663"},{"key":"bibr9-0271678X241245633","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02617-5"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X241245633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X241245633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X241245633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:15:02Z","timestamp":1777493702000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X241245633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/0271678X241245633"],"URL":"https:\/\/doi.org\/10.1177\/0271678x241245633","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,17]]}}}