{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:03:52Z","timestamp":1790643832553,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    A directional sensitivity of the cerebral pressure-flow relationship has been described using repeated squat-stands. Oscillatory lower body negative pressure (OLBNP) is a reproducible method to characterize dynamic cerebral autoregulation (dCA). It could represent a safer method to examine the directional sensitivity of the cerebral pressure-flow relationship within clinical populations and\/or during pharmaceutical administration. Therefore, examining the cerebral pressure-flow directional sensitivity during an OLBNP-induced cyclic physiological stress is crucial. We calculated changes in middle cerebral artery mean blood velocity (MCAv) per alterations to mean arterial pressure (MAP) to compute ratios adjusted for time intervals (\u0394MCAv\n                    <jats:sub>T<\/jats:sub>\n                    \/\u0394MAP\n                    <jats:sub>T<\/jats:sub>\n                    ) with respect to the minimum-to-maximum MCAv and MAP, for each OLBNP transition (0 to \u221290\u2009Torr), during 0.05\u2009Hz and 0.10\u2009Hz OLBNP. We then compared averaged \u0394MCAv\n                    <jats:sub>T<\/jats:sub>\n                    \/\u0394MAP\n                    <jats:sub>T<\/jats:sub>\n                    during OLBNP-induced MAP increases (INC) (\u0394MCAv\n                    <jats:sub>T<\/jats:sub>\n                    \/[Formula: see text]) and decreases (DEC) (\u0394MCAv\n                    <jats:sub>T<\/jats:sub>\n                    \/[Formula: see text]). Nineteen healthy participants [9 females; 30\u2009\u00b1\u20096 years] were included. There were no differences in \u0394MCAv\n                    <jats:sub>T<\/jats:sub>\n                    \/\u0394MAP\n                    <jats:sub>T<\/jats:sub>\n                    between INC and DEC at 0.05\u2009Hz. \u0394MCAv\n                    <jats:sub>T<\/jats:sub>\n                    \/[Formula: see text] (1.06\u2009\u00b1\u20090.35 vs. 1.33\u2009\u00b1\u20090.60\u2009cm\u22c5s\n                    <jats:sup>\u22121<\/jats:sup>\n                    \/mmHg; p\u2009=\u20090.0076) was lower than \u0394MCAv\n                    <jats:sub>T<\/jats:sub>\n                    \/[Formula: see text] at 0.10\u2009Hz. These results support OLBNP as a model to evaluate the directional sensitivity of the cerebral pressure-flow relationship.\n                  <\/jats:p>","DOI":"10.1177\/0271678x241247633","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T03:39:30Z","timestamp":1712979570000},"page":"1827-1839","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure"],"prefix":"10.1177","volume":"44","author":[{"given":"Lawrence","family":"Labrecque","sequence":"first","affiliation":[{"name":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrzad","family":"Soleimani Dehnavi","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoudreza","family":"Taghizadeh","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-0038","authenticated-orcid":false,"given":"Jonathan D","family":"Smirl","sequence":"additional","affiliation":[{"name":"Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada"},{"name":"Concussion Research Laboratory, Faculty of Health and Exercise Science, University of British Columbia, Kelowna, BC, Canada"},{"name":"Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, Canada"},{"name":"Integrated Concussion Research Program, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6254-5044","authenticated-orcid":false,"given":"Patrice","family":"Brassard","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"bibr1-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.152066"},{"key":"bibr2-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00790.2016"},{"key":"bibr3-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00269.2021"},{"key":"bibr4-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16648711"},{"key":"bibr5-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-182808000-00015"},{"key":"bibr6-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221119760"},{"key":"bibr7-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15626425"},{"key":"bibr8-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00264.2015"},{"key":"bibr9-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00331.2017"},{"key":"bibr10-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00653.2021"},{"key":"bibr11-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15384"},{"key":"bibr12-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1113\/EP090159"},{"key":"bibr13-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00010.2018"},{"key":"bibr14-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221142527"},{"key":"bibr15-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00332.2007"},{"key":"bibr16-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005293"},{"key":"bibr17-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.557132"},{"key":"bibr18-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.259747"},{"key":"bibr19-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1992.tb04073.x"},{"key":"bibr20-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-013-0272-9"},{"key":"bibr21-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.699121"},{"key":"bibr22-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/23\/1\/307"},{"key":"bibr23-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229049"},{"key":"bibr24-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.01.011"},{"key":"bibr25-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.177998"},{"key":"bibr26-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01390.2009"},{"key":"bibr27-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.473462"},{"key":"bibr28-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/aa9086"},{"key":"bibr29-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00854.2014"},{"key":"bibr30-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140751"},{"key":"bibr31-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00651.2014"},{"key":"bibr32-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00474.2018"},{"key":"bibr33-0271678X241247633","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-023-00986-2"}],"container-title":["Journal 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