{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:54:50Z","timestamp":1777794890242,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2025,2]]},"abstract":"\n To effectively treat cerebral arteriovenous malformations (AVMs), peri-nidal flow regulation and metabolic status must be understood. In this study, we used\n 15<\/jats:sup>\n O-oxygen positron emission tomography (PET) post-processing analysis to investigate vascular radioactivity in the nidal region of AVMs. Single-dynamic PET imaging was performed on seven unruptured AVM patients during the sequential inhalation of\n 15<\/jats:sup>\n O\n 2<\/jats:sub>\n and C\n 15<\/jats:sup>\n O\n 2<\/jats:sub>\n . A previously validated dual-tracer basis function method (DBFM) was employed to calculate parametric images. The results of our study were as follows. First, in remote and contralateral AVM regions, DBFM and a previous approach of dual-tracer autoradiography (DARG) showed strong positive correlations in cerebral blood flow (\n \n CBF<\/jats:italic>\n <\/jats:bold>\n ), cerebral oxygen metabolism rate (\n \n \n CMRO\n 2<\/jats:sub>\n <\/jats:italic>\n <\/jats:bold>\n ), and oxygen extraction fraction. Second, peri-nidal\n \n CBF<\/jats:italic>\n <\/jats:bold>\n and\n \n \n CMRO\n 2<\/jats:sub>\n <\/jats:italic>\n <\/jats:bold>\n correlation was lower, and overestimation occurred with DARG compared to with DBFM. Third, on comparing DBFM to quantitative\n 123<\/jats:sup>\n I-iodoamphetamine single-photon emission computed tomography (SPECT),\n \n CBF<\/jats:italic>\n <\/jats:bold>\n correlated significantly. In contrast, the correlation between DARG and quantitative\n 123<\/jats:sup>\n I-iodoamphetamine-SPECT was weaker in the peri-nidal regions. Fourth, analysis of tissue time-activity curves demonstrated good reproducibility using the novel formulation in the control, peri-nidus, and core nidal regions, indicating the adequacy of this approach. Overall, the DBFM approach holds promise for assessing haemodynamic alterations in patients with AVMs.\n <\/jats:p>","DOI":"10.1177\/0271678x241270416","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:41:42Z","timestamp":1723423302000},"page":"259-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative analysis of peri-nidal cerebral blood flow and metabolism using a novel quantitative\n 15<\/sup>\n O-PET method in patients with arteriovenous malformations"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-300X","authenticated-orcid":false,"given":"Daisuke","family":"Maruyama","sequence":"first","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-3068","authenticated-orcid":false,"given":"Hidehiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Koshino","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoji","family":"Nakagawara","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Morita","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hashimura","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisae","family":"Mori","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Satow","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun C","family":"Takahashi","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Fukuda","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Iihara","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroharu","family":"Kataoka","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"e_1_3_7_2_2","first-page":"498","article-title":"Arteriovenous brain malformations","volume":"377","author":"Solomon RA","year":"2017","unstructured":"Solomon RA, Connolly ESJr. Arteriovenous brain malformations. N Engl J Med 2017; 377: 498.","journal-title":"N Engl J Med"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62302-8"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012485"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000217970.18319.7d"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198411000-00003"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.68.3.0352"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn318"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/2022.4.FOCUS2210"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/2009.2.FOCUS09317"},{"key":"e_1_3_7_11_2","first-page":"2149","article-title":"Delayed data acquisition for optimal PET activation studies with oxygen-15-water in cerebral arteriovenous malformation","volume":"36","author":"Okazawa H","year":"1995","unstructured":"Okazawa H, Yonekura Y, Sadato N, et\u00a0al. Delayed data acquisition for optimal PET activation studies with oxygen-15-water in cerebral arteriovenous malformation. J Nucl Med 1995; 36: 2149\u20132153.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.188"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-018-0236-5"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600118"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/59\/18\/5593"},{"key":"e_1_3_7_16_2","first-page":"2019","article-title":"Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT","volume":"35","author":"Iida H","year":"1994","unstructured":"Iida H, Itoh H, Nakazawa M, et\u00a0al. Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT. J Nucl Med 1994; 35: 2019\u20132030.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00003"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00181062"},{"key":"e_1_3_7_19_2","first-page":"498","article-title":"A new graphic plot analysis for cerebral blood flow and partition coefficient with iodine-123-iodoamphetamine and dynamic SPECT validation studies using oxygen-15-water and PET","volume":"34","author":"Yokoi T","year":"1993","unstructured":"Yokoi T, Iida H, Itoh H, et\u00a0al. A new graphic plot analysis for cerebral blood flow and partition coefficient with iodine-123-iodoamphetamine and dynamic SPECT validation studies using oxygen-15-water and PET. J Nucl Med 1993; 34: 498\u2013505.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.078352"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3309-5"},{"key":"e_1_3_7_22_2","first-page":"181","article-title":"Effects of scatter and attenuation correction on quantitative assessment of regional cerebral blood flow with SPECT","volume":"39","author":"Iida H","year":"1998","unstructured":"Iida H, Narita Y, Kado H, et\u00a0al. Effects of scatter and attenuation correction on quantitative assessment of regional cerebral blood flow with SPECT. J Nucl Med 1998; 39: 181\u2013189.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_23_2","first-page":"512","article-title":"Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities","volume":"44","author":"Kim KM","year":"2003","unstructured":"Kim KM, Varrone A, Watabe H, et\u00a0al. Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities. J Nucl Med 2003; 44: 512\u2013519.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02988446"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1431-7"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-014-0879-9"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.06.064"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231220691"},{"key":"e_1_3_7_29_2","first-page":"177","article-title":"Brain oxygen utilisation was measured with O-15 radiotracers and positron emission tomography","volume":"25","author":"Mintun MA","year":"1984","unstructured":"Mintun MA, Raichle ME, Martin WR, et\u00a0al. Brain oxygen utilisation was measured with O-15 radiotracers and positron emission tomography. J Nucl Med 1984; 25: 177\u2013187.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_30_2","first-page":"1333","article-title":"Modeling approach to eliminate the need to separate arterial plasma in oxygen-15 inhalation positron emission tomography","volume":"34","author":"Iida H","year":"1993","unstructured":"Iida H, Jones T, Miura S. Modeling approach to eliminate the need to separate arterial plasma in oxygen-15 inhalation positron emission tomography. J Nucl Med 1993; 34: 1333\u20131340.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_31_2","first-page":"192","article-title":"Integrated software for analysing brain PET\/SPECT studies with partial-volume-effect correction","volume":"45","author":"Quarantelli M","year":"2004","unstructured":"Quarantelli M, Berkouk K, Prinster A, et\u00a0al. Integrated software for analysing brain PET\/SPECT studies with partial-volume-effect correction. J Nucl Med 2004; 45: 192\u2013201.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.4.0476"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1988.60"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.121"},{"key":"e_1_3_7_35_2","first-page":"2339","article-title":"Cerebral blood flow measurement with iodine-123-IMP SPECT, calibrated standard input function and venous blood sampling","volume":"36","author":"Ito H","year":"1995","unstructured":"Ito H, Koyama M, Goto R, et\u00a0al. Cerebral blood flow measurement with iodine-123-IMP SPECT, calibrated standard input function and venous blood sampling. J Nucl Med 1995; 36: 2339\u20132342.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.6.0967"},{"key":"e_1_3_7_37_2","first-page":"341","volume-title":"A manual of disease of the nervous system","author":"Gowers WR.","year":"1888","unstructured":"Gowers WR. A manual of disease of the nervous system. Volume 2. London: J & A Churchill, 1888. 341\u2013351."},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/neurosurgery\/25.CN_suppl_1.651"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.890"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520080027015"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1983.59.1.0021"},{"key":"e_1_3_7_42_2","first-page":"441","article-title":"Use of acetazolamide-challenge xenon CT in assessing cerebral blood flow dynamics in patients with arteriovenous malformations","volume":"11","author":"Tarr RW","year":"1990","unstructured":"Tarr RW, Johnson DW, Rutigliano M, et\u00a0al. Use of acetazolamide-challenge xenon CT in assessing cerebral blood flow dynamics in patients with arteriovenous malformations. AJNR Am J Neuroradiol 1990; 11: 441\u2013448.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.12.2623"},{"key":"e_1_3_7_44_2","first-page":"1865","article-title":"Adaptive changes of autoregulation in chronic cerebral hypotension with arteriovenous malformations: an acetazolamide-enhanced single-photon emission CT study","volume":"16","author":"Hacein-Bey L","year":"1995","unstructured":"Hacein-Bey L, Nour R, Pile-Spellman J, et\u00a0al. Adaptive changes of autoregulation in chronic cerebral hypotension with arteriovenous malformations: an acetazolamide-enhanced single-photon emission CT study. AJNR Am J Neuroradiol 1995; 16: 1865\u20131874.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.7.1215"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199404000-00006"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.78.2.0167"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.6.1314"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq286"},{"key":"e_1_3_7_50_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000255491.95944.EB"},{"key":"e_1_3_7_51_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000097518.57741.BE"},{"key":"e_1_3_7_52_2","first-page":"1672","article-title":"PET and the autoradiographic method with continuous inhalation of oxygen-15-gas: theoretical analysis and comparison with conventional steady-state methods","volume":"34","author":"Sadato N","year":"1993","unstructured":"Sadato N, Yonekura Y, Senda M, et\u00a0al. PET and the autoradiographic method with continuous inhalation of oxygen-15-gas: theoretical analysis and comparison with conventional steady-state methods. J Nucl Med 1993; 34: 1672\u20131680. 1993\/10\/01.","journal-title":"J Nucl Med"},{"key":"e_1_3_7_53_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-65-776-697"}],"container-title":["Journal of Cerebral Blood Flow & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X241270416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X241270416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X241270416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:15:11Z","timestamp":1777493711000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X241270416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,11]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/0271678X241270416"],"URL":"https:\/\/doi.org\/10.1177\/0271678x241270416","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,11]]}}}