{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:22:34Z","timestamp":1777944154551,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>Extracorporeal cardiopulmonary resuscitation (ECPR) facilitates resuscitation with immediate and precise temperature control. This study aimed to determine the optimal reperfusion temperature to minimize neurological damage after ventricular fibrillation cardiac arrest (VFCA). Twenty-four rats were randomized (n\u2009=\u20098 per group) to normothermia (NT\u2009=\u200937\u00b0C), mild hypothermia (MH\u2009=\u200933\u00b0C) or moderate hypothermia (MOD\u2009=\u200927\u00b0C). The rats were subjected to 10 minutes of VFCA, before 15 minutes of ECPR at their respective target temperature. After ECPR weaning, rats in the MOD group were rapidly rewarmed to 33\u00b0C, and temperature maintained at 33\u00b0C (MH\/MOD) or 37\u00b0C (NT) for 12 hours before slow rewarming to normothermia (MH\/MOD). The primary outcome was 30-day survival with overall performance category (OPC) 1 or 2 (1\u2009=\u2009normal, 2\u2009=\u2009slight disability, 3\u2009=\u2009severe disability, 4\u2009=\u2009comatose, 5\u2009=\u2009dead). Secondary outcomes included awakening rate (OPC\u2009\u2264\u20093) and neurological deficit score (NDS, from 0\u2009=\u2009normal to 100\u2009=\u2009brain dead). The survival rate did not differ between reperfusion temperatures (NT\u2009=\u200925%, MH\u2009=\u200963%, MOD\u2009=\u200938%, p\u2009=\u20090.301). MH had the lowest NDS (NT\u2009=\u20094[IQR 3\u20134], MH\u2009=\u20092[1\u20132], MOD\u2009=\u20095[3\u20135], p\u2009=\u20090.044) and highest awakening rate (NT\u2009=\u200925%, MH\u2009=\u200988%, MOD\u2009=\u200975%, p\u2009=\u20090.024). In conclusion, ECPR with 33\u00b0C reperfusion did not statistically significantly improve survival after VFCA when compared with 37\u00b0C or 27\u00b0C reperfusion but was neuroprotective as measured by awakening rate and neurological function.<\/jats:p>","DOI":"10.1177\/0271678x241281485","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T08:58:18Z","timestamp":1725958698000},"page":"476-485","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroprotection with hypothermic reperfusion and extracorporeal cardiopulmonary resuscitation \u2013 A randomized controlled animal trial of prolonged ventricular fibrillation cardiac arrest in rats"],"prefix":"10.1177","volume":"45","author":[{"given":"Ingrid","family":"Magnet","sequence":"first","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-3450","authenticated-orcid":false,"given":"Alexandra-Maria","family":"Stommel","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schriefl","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Mueller","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Poppe","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Grafeneder","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Testori","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Janata","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schober","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Klinik Floridsdorf, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Grassmann","sequence":"additional","affiliation":[{"name":"Emergency Medical Service Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Behringer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Weihs","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Holzer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Hoegler","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Ettl","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32338-2"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.1025"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204511"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.02.010"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1670-9"},{"key":"e_1_3_4_7_2","first-page":"CD004128","article-title":"Hypothermia for neuroprotection in adults after cardiac arrest","volume":"5","author":"Arrich J","year":"2023","unstructured":"Arrich J, Sch\u00fctz N, Oppenauer J, et\u00a0al. 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