{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:39:41Z","timestamp":1792157981473,"version":"4.4.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    Perfusion imaging is useful to assess tissue recovery in patients with acute ischemic stroke (AIS); however, it cannot reflect tissue metabolism. We postulated that amide proton transfer (APT) imaging can characterize the tissue status after reperfusion therapy, thus providing prognostic value for 90-day functional outcomes. We included 63 patients with AIS and large-vessel occlusion (LVO). The APT signals, including APT\n                    <jats:sup>#<\/jats:sup>\n                    and NOE\n                    <jats:sup>#<\/jats:sup>\n                    (nuclear Overhauser enhancement) were quantified. Ischemic lesions observed on APT\n                    <jats:sup>#<\/jats:sup>\n                    and diffusion-weighted imaging (DWI) were classified according to their mismatch patterns (APT\n                    <jats:sup>#<\/jats:sup>\n                    \u2009&lt;\u2009DWI; APT\n                    <jats:sup>#<\/jats:sup>\n                    \u2265 DWI). Predictors of 90-day good outcomes (modified Rankin scale score 0\u20132) were evaluated. Patients with successful reperfusion exhibited higher APT\n                    <jats:sup>#<\/jats:sup>\n                    , smaller percentage change of APT\n                    <jats:sup>#<\/jats:sup>\n                    , and a greater likelihood of presenting APT\n                    <jats:sup>#<\/jats:sup>\n                    \u2009&lt;\u2009DWI compared to those with poor reperfusion (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). The APT\n                    <jats:sup>#<\/jats:sup>\n                    (odds ratio [OR]\u2009=\u200911.48,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.046) and a mismatch pattern of APT\n                    <jats:sup>#<\/jats:sup>\n                    \u2009&lt;\u2009DWI (OR\u2009=\u20097.41,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.020) independently predicted good outcomes besides the clinical parameters. A mismatch pattern of APT\n                    <jats:sup>#<\/jats:sup>\n                    \u2265 DWI was a significant marker of poor outcomes despite successful reperfusion (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.002). Our study provides preliminary evidence that APT may reveal tissue recovery after reperfusion and predict good outcomes at 90 days in patients with AIS and LVO.\n                  <\/jats:p>","DOI":"10.1177\/0271678x241297110","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T06:48:12Z","timestamp":1730357292000},"page":"421-430","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Amide proton transfer MRI may reflect effective reperfusion and predict functional outcomes in patients with ischemic stroke"],"prefix":"10.1177","volume":"45","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwang","family":"Yong","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering & Instrument Science, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhou","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cheng","family":"Hsu","sequence":"additional","affiliation":[{"name":"MR Collaboration, Siemens Healthcare Ltd., Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering & Instrument Science, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4213-9908","authenticated-orcid":false,"given":"Shanshan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68770-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017701147"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103340"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.543595"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000143222.13069.70"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008481"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017283"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231155222"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17700913"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm907"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.07.025"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu374"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5964-3"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101833"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29660"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28513"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27663"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12068"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011482"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.568766"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.526814"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221148970"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000528922"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001172"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231208993"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26799"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394309-5.00006-7"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.091"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009173"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.024263"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00901"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00104"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.038466"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00868-z"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4699"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28184"}],"container-title":["Journal 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