{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:37:10Z","timestamp":1793914630209,"version":"4.8.0"},"reference-count":122,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Spontaneous intracerebral hemorrhage(ICH) represents a life-threatening form of stroke, marked by its impact on survival and quality of life. ICH can be categorized from monogenic disorders linked to causal germline variants in ICH-related genes to complex sporadic cases, highlighting the interaction among lifestyle factors, environmental influences, and genetic components in determining risk. Among sporadic ICH, the influence of these factors varies across ICH subtypes, evidenced by heritability rates of up to 73% for lobar ICH versus 34% for non-lobar ICH. This review presents an outline of the genetic landscape of ICH, covering both monogenic and sporadic forms. It highlights associations between ICH risk and genetic variants, including rare and common variants in genes such as\n                    <jats:italic toggle=\"yes\">COL4A1, COL4A2, APOE, ACE, MTHFR,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">PMF1<\/jats:italic>\n                    . However, replication has been constrained, and most findings originate from single-candidate gene studies, largely due to ancestry heterogeneity, small sample sizes, and scarce subtype-specific data. To bridge this gap, collaborative efforts like the International Stroke Genetic Consortium have been established. Additionally, the review discusses the emerging role of polygenic risk scores, Mendelian randomization, and the potential of genetic and omics research to elucidate causal pathobiology. Such insights could lead to preventive measures and personalized ICH treatment strategies.\n                  <\/jats:p>","DOI":"10.1177\/0271678x241310401","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T03:20:58Z","timestamp":1736220058000},"page":"1324-1340","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetics of intracerebral hemorrhage"],"prefix":"10.1177","volume":"46","author":[{"given":"Tamara N","family":"Kimball","sequence":"first","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier WP","family":"Tack","sequence":"additional","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Chen","sequence":"additional","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savvina","family":"Prapiadou","sequence":"additional","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper R","family":"Senff","sequence":"additional","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin YQ","family":"Tan","sequence":"additional","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjula D","family":"Singh","sequence":"additional","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-8643","authenticated-orcid":false,"given":"Susanne J","family":"van Veluw","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rosand","sequence":"additional","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-2002","authenticated-orcid":false,"given":"Christopher D","family":"Anderson","sequence":"additional","affiliation":[{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Massachusetts General Hospital"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.226"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70025-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000208400.08722.7c"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70340-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Labovitz DL Halim A Boden-Albala B et\u00a0al. The incidence of deep and lobar intracerebral hemorrhage in whites blacks and Hispanics. Neurology 2005; 65: 518\u2013522.","DOI":"10.1212\/01.wnl.0000172915.71933.00"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201720"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.1.1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00208-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.7.1418"},{"key":"e_1_3_2_11_2","first-page":"100124","article-title":"Main features of hereditary cerebral amyloid angiopathies: a systematic review","volume":"3","author":"Biffi A.","year":"2022","unstructured":"Biffi A. Main features of hereditary cerebral amyloid angiopathies: a systematic review. Cereb Circ Cogn Behav 2022; 3: 100124.","journal-title":"Cereb Circ Cogn Behav"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a024539"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2949367"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111584"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003181"},{"key":"e_1_3_2_16_2","first-page":"S28","article-title":"A new \u00dfPP mutation related to hereditary cerebral haemorrhage","volume":"2","author":"Tagliavini F","year":"1999","unstructured":"Tagliavini F, Rossi G, Padovani A, et\u00a0al. A new \u00dfPP mutation related to hereditary cerebral haemorrhage. Alzheimer\u2019s Reports 1999; 2: S28.","journal-title":"Alzheimer\u2019s Reports"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1009"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000050140.10044.A8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"van Duijn CM Cras P Cruts M et\u00a0al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the amyloid precursor protein gene. Nature genetics 1992; 3: 218\u2013221.","DOI":"10.1038\/ng0692-218"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142965.10778.C7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90641-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(92)90031-W"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02235-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.19943"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011050"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001834"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03040"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105315"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.14806\/ej.24.0.921"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12722"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","unstructured":"RA Berg AMK. Familial porencephaly Archieves of Neurology 1983; 40: 567\u2013569.","DOI":"10.1001\/archneur.1983.04050080067013"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109418"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds346"},{"key":"e_1_3_2_34_2","unstructured":"Anne Amemiya EP. COL4A1-Related Disorders https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK7046\/ (2009 accessed 22 February 2024)."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.022"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.42"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.210"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01986897"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1898.tb16317.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2022.07.010"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-016-0309-z"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-14"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020271"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006316"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-024-03028-w"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2016-104178"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000497"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0088-3"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12181"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440506"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065482"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801560"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418087111"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv155"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182768954"},{"key":"e_1_3_2_56_2","doi-asserted-by":"crossref","unstructured":"Bugiani M Kevelam SH Bakels HS et\u00a0al. Cathepsin A\u2013related arteriopathy with strokes and leukoencephalopathy (CARASAL). Neurology 2016; 87: 1777\u20131786.","DOI":"10.1212\/WNL.0000000000003251"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003271"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2023.03.005"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0639-8"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.04.014"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.09.009"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.50.590.774"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1159\/000048609"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000227409.59195.d1"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000014774.88027.22"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000089"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0389-5"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01026-w"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1608"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.012682"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031792"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz233"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.38"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31818131e7"},{"key":"e_1_3_2_75_2","volume-title":"Methods in enzymology","author":"Zannis VI.","unstructured":"Zannis VI. Genetic polymorphism in human apolipoprotein E. Methods in enzymology 1986; 128: 823\u2013851."},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.1.1.507"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22134"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4519"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.138.1.312"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.09.026"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22277"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182452b40"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030782"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.02.012"},{"key":"e_1_3_2_86_2","doi-asserted-by":"crossref","unstructured":"Parodi L Comeau ME Georgakis MK et\u00a0al. Deep resequencing of the 1q22 locus in non-lobar intracerebral hemorrhage. Annals in Neurology 2024; 325: 325\u2013337.","DOI":"10.1002\/ana.26814"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11248-010-9422-5"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22682"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004560"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.827165"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012227"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003395"},{"key":"e_1_3_2_93_2","doi-asserted-by":"crossref","unstructured":"Choi SW H Mak TS O\u2019Reilly PF. A guide to performing polygenic risk score analyses. Preprint. Genomics. Epub Ahead of Print 2018; 14.","DOI":"10.1101\/416545"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13848-1"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.041701"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00742-5"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.03.004"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01348-y"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2016.00864"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25740"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25686"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.2299"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.046249"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008737"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.21921"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002332"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.702244"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947601910393957"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.029862"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-018-0633-z"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053727"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23736"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810088"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0521-2"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01309.x"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2010.18"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr063"},{"key":"e_1_3_2_118_2","first-page":"100139","article-title":"Cognitive aspects of MELAS and CARASAL","volume":"3","author":"Canavero I","year":"2022","unstructured":"Canavero I, Rifino N, Montano V, et\u00a0al. Cognitive aspects of MELAS and CARASAL. Cereb Circ Cogn Behav 2022; 3: 100139.","journal-title":"Cereb Circ Cogn Behav"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.12.006"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24780"},{"key":"e_1_3_2_121_2","doi-asserted-by":"crossref","first-page":"e01840","DOI":"10.1002\/brb3.1840","article-title":"Associations between MTHFR gene polymorphisms and the risk of intracranial hemorrhage: evidence from a meta\u2010analysis","volume":"11","author":"Wang F","year":"2021","unstructured":"Wang F, Xu Z, Jiao H, et\u00a0al. Associations between MTHFR gene polymorphisms and the risk of intracranial hemorrhage: evidence from a meta\u2010analysis. Brain Behav 2021; 11: e01840.","journal-title":"Brain Behav"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1877-3"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.2972"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X241310401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X241310401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X241310401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:08:53Z","timestamp":1789459733000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X241310401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":122,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/0271678X241310401"],"URL":"https:\/\/doi.org\/10.1177\/0271678x241310401","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}