{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:56:09Z","timestamp":1777794969650,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    Obtaining the arterial input function (AIF) is essential for quantitative regional cerebral perfusion (rCBF) measurements using [\n                    <jats:sup>15<\/jats:sup>\n                    O]H\n                    <jats:sub>2<\/jats:sub>\n                    O PET. However, arterial blood sampling is invasive and complicates the scanning procedure. We propose a new non-invasive dual scan technique with an image derived input function (IDIF) from an additional heart scan. Six patients and two healthy subjects underwent [\n                    <jats:sup>15<\/jats:sup>\n                    O]H\n                    <jats:sub>2<\/jats:sub>\n                    O PET imaging of 1) heart and brain during baseline, and 2) heart and brain after infusion of acetazolamide. The IDIF was extracted from the left ventricle of the heart and compared to the AIF. The rCBF was compared for six bilateral cortical regions. AIFs and IDIFs showed strong agreement. rCBF with AIF and IDIF showed strong correlation for both baseline rCBF (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.99, slope\u2009=\u20090.89 CI: [0.87; 0.91], p\u2009&lt;\u20090.0001) and acetazolamide rCBF (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.98, slope\u2009=\u20090.93, CI:[0.90;0.97], p\u2009&lt;\u20090.0001) but showed a positive bias of 0.047\u2009mL\/(g\u00b7min) [\u22120.025; +0.119] for baseline and 0.024 [\u22121.04, +1.53] mL\/(g\u00b7min) for acetazolamide. In conclusion, the invasive arterial cannulation can be replaced by an additional scan of the heart with a minor bias of rCBF estimation. The method is applicable to all scanner systems.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251313743","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T04:18:47Z","timestamp":1737346727000},"page":"1144-1152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-invasive [\n                    <sup>15<\/sup>\n                    O]H\n                    <sub>2<\/sub>\n                    O PET measurements of cerebral perfusion and cerebrovascular reactivity using an additional heart scan"],"prefix":"10.1177","volume":"45","author":[{"given":"Mathias Jacobsen","family":"Bach","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia E","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda O","family":"Kellberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander C","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"},{"name":"Department of Radiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Fuglsang","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge Lise","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus Nowak","family":"Lonsdale","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Lubberink","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-5742","authenticated-orcid":false,"given":"Lisbeth","family":"Marner","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3238165"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012781"},{"key":"e_1_3_6_4_2","first-page":"S0001","article-title":"[15O]H2O PET: potential or essential for molecular imaging?","volume":"26","author":"Slart RHJA","year":"2023","unstructured":"Slart RHJA, Martinez-Lucio TS, Boersma HH, et\u00a0al. [15O]H2O PET: potential or essential for molecular imaging? Semin Nucl Med 2023; 26: S0001.","journal-title":"Semin Nucl Med"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107466"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2014.09.010"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.107"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-06057-4"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-023-01050-w"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23579"},{"key":"e_1_3_6_11_2","first-page":"1789","article-title":"Noninvasive quantitation of cerebral blood flow using oxygen-15-water and a dual-PET system","volume":"39","author":"Iida H","year":"1998","unstructured":"Iida H, Miura S, Shoji Y, et\u00a0al. Noninvasive quantitation of cerebral blood flow using oxygen-15-water and a dual-PET system. J Nucl Med 1998; 39: 1789\u20131798.","journal-title":"J Nucl Med"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-024-06716-8"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119079"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1986.99"},{"key":"e_1_3_6_15_2","first-page":"292","article-title":"Non-invasive quantification of tumor blood flow in prostate cancer using [15O]-H2O PET\/CT","volume":"8","author":"Tolbod LP","year":"2018","unstructured":"Tolbod LP, Nielsen MM, Pedersen BG, et\u00a0al. Non-invasive quantification of tumor blood flow in prostate cancer using [15O]-H2O PET\/CT. Am J Nucl Med Mol Imaging 2018; 8: 292\u2013302.","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X21991393"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aa6a95"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.05.033"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01728767"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2018.2890459"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1109\/4233.908397"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-018-0412-6"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-023-00535-w"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.203414"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.117950"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/6\/1903"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17691784"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251313743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X251313743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251313743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:15:27Z","timestamp":1777493727000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X251313743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1177\/0271678X251313743"],"URL":"https:\/\/doi.org\/10.1177\/0271678x251313743","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]}}}