{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:48:49Z","timestamp":1789944529584,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Brain arteriovenous malformations (bAVMs) are a notable cause of intracranial hemorrhage, strongly associated with severe morbidity and mortality. Contemporary treatment options include surgery, stereotactic radiosurgery, and endovascular embolization, each of which has limitations. Hence, development of pharmacological interventions is urgently needed. The recent discovery of the presence of activating Kirsten rat sarcoma (\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    ) viral oncogene homologue mutations in most sporadic bAVMs has opened the door for a more comprehensive understanding of the pathogenesis of bAVMs and has pointed to entirely novel possible therapeutic targets. Herein, we review the status quo of genetics, animal models, and therapeutic approaches in bAVMs.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251319913","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T22:16:11Z","timestamp":1739484971000},"page":"793-799","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Advances in sporadic brain arteriovenous malformations: Novel genetic insights, innovative animal models and emerging therapeutic approaches"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5708-3380","authenticated-orcid":false,"given":"Yasuhito","family":"Ueki","sequence":"first","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic Rochester, MN, USA"},{"name":"Department of Neurosurgery, Faculty of Medicine, The University of Juntendo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M","family":"Naylor","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherief A","family":"Ghozy","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasthuri","family":"Thirupathi","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F","family":"Kallmes","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanathan","family":"Kadirvel","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic Rochester, MN, USA"},{"name":"Department of Radiology, Mayo Clinic Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62302-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30181-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.4.0476"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2020.11.JNS203298"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199604000-00004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.6.0912"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199512000-00001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199609000-00004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709449"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316500"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317722"},{"key":"e_1_3_2_14_2","first-page":"767","article-title":"Advances in the study of KRAS in brain arteriovenous malformation","volume":"53","author":"Pang M","year":"2024","unstructured":"Pang M, Zhang G, Shang C, et\u00a0al. Advances in the study of KRAS in brain arteriovenous malformation. Cerebrovasc Dis 2024; 53: 767\u2013775.","journal-title":"Cerebrovasc Dis"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.639361"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318145"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309160"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-024-09918-8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy307"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.03.105"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.04.004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226852"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3171\/2020.11.JNS202031"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019920982810"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26059"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddac169"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjno-2020-000114"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4389"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.12.001"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ml200004g"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-3206"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-188070"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.647982"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.024"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251319913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X251319913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251319913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:47:32Z","timestamp":1777708052000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X251319913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/0271678X251319913"],"URL":"https:\/\/doi.org\/10.1177\/0271678x251319913","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]}}}