{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:41:48Z","timestamp":1785768108994,"version":"3.56.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Neurofibrillary tangles (NFTs), composed of aggregated tau protein, in the brain is a neuropathological hallmark and feature of Alzheimer\u2019s disease (AD) and other tauopathies. One promising approach to prevent tau aggregates is to inhibit O-GlcNAcase (OGA), an enzyme that regulates tau O-GlcNAcylation. [\n                    <jats:sup>11<\/jats:sup>\n                    C]BIO-1819578 has emerged as a promising candidate to determine target occupancy of such OGA inhibitor drugs. The aim of this study was to further evaluate the pharmacokinetic properties of [\n                    <jats:sup>11<\/jats:sup>\n                    C]BIO-1819578 in non-human primates (NHPs) and to estimate its effective dose. Kinetic compartment analyses of [\n                    <jats:sup>11<\/jats:sup>\n                    C]BIO-1819578 binding to OGA in the brain were performed on positron emission tomography (PET) measurements conducted in three cynomolgus NHPs. Whole-body PET measurements were carried out in two NHPs to estimate the effective radiation dose. Both the 1-tissue-compartment (1TCM) and 2-tissue-compartment model (2TCM) could describe the regional time activity curves of [\n                    <jats:sup>11<\/jats:sup>\n                    C]BIO-1819578. The 2TCM was the statistically preferred model. The effective radiation dose was estimated to be 0.0033 mSv\/MBq. The results showed that [\n                    <jats:sup>11<\/jats:sup>\n                    C]BIO-1819578 has suitable characteristics for reliable quantification of OGA using full kinetic modelling. The effective dose was on par with other\n                    <jats:sup>11<\/jats:sup>\n                    C radioligands and is unlikely to pose an issue for human use.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251332487","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:14:12Z","timestamp":1744478052000},"page":"1606-1616","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["In vivo quantification of [\n                    <sup>11<\/sup>\n                    C]BIO-1819578 in non-human primates, a novel radioligand for O-GlcNAcase"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-6401","authenticated-orcid":false,"given":"Martin","family":"Bolin","sequence":"first","affiliation":[{"name":"Karolinska 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