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Although movement disorders are prominent in PD, sensory impairments also occur relatively early on, mainly in olfactory and, to a lesser extent visual systems. While these deficits have been described mainly at the behavioral and molecular levels, the underlying network-level activity remains poorly understood. Here, we harnessed a human\n                    <jats:inline-formula>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                        <mml:mi>\u03b1<\/mml:mi>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    Syn transgenic mouse model of PD with\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    functional MRI (fMRI) to map evoked activity in the visual and olfactory pathways, along with pseudo-Continuous Arterial Spin Labeling (pCASL) and c-FOS measurements to disentangle vascular from neuronal effects. Upon stimulation with either odors or flickering lights, we found significant decreases in fMRI responses along both olfactory and visual pathways, in multiple cortical and subcortical sensory areas. Average Cerebral Blood Flow rates were decreased by \u223c10% in the\n                    <jats:inline-formula>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                        <mml:mi>\u03b1<\/mml:mi>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    Syn group, while c-FOS levels were reduced by over 50%, suggesting a strong neural driver for the dysfunction, along with more modest vascular contributions. Our study provides insight into brain-level activity in an\n                    <jats:inline-formula>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                        <mml:mi>\u03b1<\/mml:mi>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    Syn-based model, and suggests a novel target for biomarking via quantification of simple sensory evoked responses.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251338952","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T19:01:27Z","timestamp":1746644487000},"page":"1654-1669","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson\u2019s disease"],"prefix":"10.1177","volume":"45","author":[{"given":"Ruxanda","family":"Lungu","sequence":"first","affiliation":[{"name":"Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7967-067X","authenticated-orcid":false,"given":"Francisca F","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Pires Monteiro","sequence":"additional","affiliation":[{"name":"Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal"},{"name":"Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior T\u00e9cnico \u2013 Universidade de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago F","family":"Outeiro","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurodegeneration, University Medical Center G\u00f6ttingen, Center for Biostructural Imaging of Neurodegeneration, G\u00f6ttingen, Germany"},{"name":"Max Planck Institute for Multidisciplinary Sciences, G\u00f6ttingen, Germany"},{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK"},{"name":"Scientific Employee with an Honorary Contract at German Center for Neurodegenerative Diseases (DZNE), G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-5876","authenticated-orcid":false,"given":"Noam","family":"Shemesh","sequence":"additional","affiliation":[{"name":"Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031851"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-019-0165-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49402-x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00592-z"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182929f62"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146847"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102374"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac165"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22577"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-021-02731-w"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46991-3"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.11.079"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1199"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.010"},{"key":"e_1_3_3_17_2","first-page":"1","article-title":"Olfactory loss in Parkinson\u2019s disease","volume":"2011","author":"Haehner A","year":"2011","unstructured":"Haehner A, Hummel T, Reichmann H. 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