{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:35:23Z","timestamp":1791578123732,"version":"4.3.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    Stroke imposes significant global socio-economic burdens, yet the absence of clinically approved anti-ischemic drugs and limited thrombolysis availability underscore the critical need for novel therapeutic target. To identify novel anti-ischemic therapeutic targets, we conducted a comprehensive proteomics analysis subsequent to in vitro ischemia\/reperfusion of epithelial cells highly sensitive to oxygen deprivation with and without eIF5A inhibition, a strategy recently acknowledged for its efficacy in alleviating ischemic-anoxic damage. We identified seryl-tRNA synthetase (serRS) as a promising target through several key findings. Initially, we validated its inhibition as highly efficient in reducing cell death in an\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    model of ischemia\/reperfusion. Subsequently, we demonstrated that inhibition of serRS substantially decreased infarct volume and alleviated both motor and cognitive deficits in a murine model of transient focal cerebral ischemia, underscoring the\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    therapeutic potential of targeting serRS. Overall, this Proof-of-Concept study unveils serRS as a novel anti-ischemic target, laying groundwork for the discovery and development of new inhibitors with therapeutic promise against ischemic-related diseases.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251347810","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:16:17Z","timestamp":1750317377000},"page":"2161-2173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Targeting seryl-tRNA synthetase to unlock ischemic resilience in stroke \u2013 Insights from a proof-of-concept study"],"prefix":"10.1177","volume":"45","author":[{"given":"Miled","family":"Bourourou","sequence":"first","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, CNRS UMR7275, INSERM U1323, IPMC, Sophia Antipolis, 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