{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:39:37Z","timestamp":1792157977541,"version":"4.4.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>We hypothesized that cerebral small vessel disease (CSVD) burden might not relevantly affect leptomeningeal collateral supply in patients with acute ischemic stroke (AIS) due to large-vessel occlusion (LVO). In n\u2009=\u2009154 patients with anterior circulation LVO, CSVD imaging markers (white matter hyperintensities [WMH], lacunes, cerebral microbleeds and enlarged perivascular spaces) were assessed with MRI, using established criteria. Besides the extent of WMH, assessed using total Fazekas sum score, overall CSVD burden was determined with a total CSVD summary score ranging from 0\u20134. A quantitative and rater-independent collateral vessel index was computed from automated processing of T2*-weighted time series in perfusion-weighted imaging (PWI) to assess the pial collateral status. The overall burden of WMH and CSVD were not significantly associated with poor collaterals (adjusted odds ratios 0.830 (0.328\u20132.104) and 0.995 (0.666\u20131.488), p\u2009=\u20090.695 and p\u2009=\u20090.982) and did not modify the significant relationship of leptomeningeal collaterals with clinical stroke severity, ischemic core volume and infarct growth rate. Quantitative and objective analysis of collaterals with a signal variance-based approach in PWI revealed no overt association between CSVD burden and collaterals in LVO patients. Factors favoring or impairing collateral supply in case of acute cerebral ischemia warrant further exploration in future studies.<\/jats:p>","DOI":"10.1177\/0271678x251358972","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:56:26Z","timestamp":1753710986000},"page":"66-77","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral small vessel disease does not impair leptomeningeal collateral supply in large-vessel occlusion \u2013 Results from quantitative collateral mapping with MRI"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2363-4658","authenticated-orcid":false,"given":"Christoph","family":"Polkowski","sequence":"first","affiliation":[{"name":"Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Helwig","sequence":"additional","affiliation":[{"name":"Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Seker","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus A","family":"M\u00f6hlenbruch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9502-1984","authenticated-orcid":false,"given":"Alexander","family":"Seiler","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"},{"name":"Neurovascular Center, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034471"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004072"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595256"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.604603"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.004781"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213443"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.242401"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X251322378"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18800589"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013392"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18602"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23906"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.02.018"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1181001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03266-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.869329"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025142"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037869"},{"key":"e_1_3_2_23_2","article-title":"Response by lin to letter regarding article, \u201cCollateral recruitment is impaired by cerebral small vessel disease\u201d","volume":"51","author":"Lin MP.","year":"2020","unstructured":"Lin MP. Response by lin to letter regarding article, \u201cCollateral recruitment is impaired by cerebral small vessel disease\u201d. Stroke 2020; 51: e166.","journal-title":"Stroke"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030322"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19831024"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19898148"},{"key":"e_1_3_2_27_2","article-title":"Leptomeningeal collateral status by signal variance in perfusion magnetic resonance imaging: association with initial stroke severity and early functional outcome after thrombectomy","volume":"3","author":"Helwig N","year":"2023","unstructured":"Helwig N, Seker F, M\u00f6hlenbruch MA, et\u00a0al. Leptomeningeal collateral status by signal variance in perfusion magnetic resonance imaging: association with initial stroke severity and early functional outcome after thrombectomy. Stroke-Vasc Interv N 2023; 3: e000776.","journal-title":"Stroke-Vasc Interv N"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4415-2"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12068"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873241226771"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11113102"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12436"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00012"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00131-X"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027661"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03517-8"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.351"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X241292537"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031736"},{"key":"e_1_3_2_40_2","first-page":"70","article-title":"Occurence and variability in acute formation of leptomeningeal collaterals in proximal middle cerebral artery occlusion","volume":"1","author":"Qureshi AI","year":"2008","unstructured":"Qureshi AI, El-Gengaihi A, Hussein HM, et\u00a0al. Occurence and variability in acute formation of leptomeningeal collaterals in proximal middle cerebral artery occlusion. J Vasc Interv Neurol 2008; 1: 70\u201372.","journal-title":"J Vasc Interv Neurol"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11099-7"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008317"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103549"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-024-01277-2"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030912"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207908"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025608"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00512.x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023407"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24211"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17744716"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-024-01456-6"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1423967"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251358972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X251358972","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251358972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:36Z","timestamp":1777493556000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X251358972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/0271678X251358972"],"URL":"https:\/\/doi.org\/10.1177\/0271678x251358972","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]}}}