{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:14:39Z","timestamp":1778811279451,"version":"3.51.4"},"reference-count":74,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Early diagnosis of ischemic stroke is crucial for timely intervention and saving brain function. The mechanisms of stroke are complex, involving multiple parameters such as blood flow perfusion, tissue status, and oxygenation levels. These parameters interact with each other, necessitating multiple systems to evaluate. The animal model must be moved among systems for various systems monitoring, which complicates the operation and may induce additional interference. Here, we propose a non-contact all-optic OCT-PAM dual-mode imaging system for monitoring rat cortex states. The compact probe enables facilitating long-term multi-parameter observation. Using the system, we quantitatively monitored the state of the rat cortex of ischemic stroke during the acute phase, including blood perfusion density, vessel diameter, vessel length, optical attenuation coefficient, and photoacoustic absorption. We observed reduced perfusion in the affected cortex, contralateral perfusion increases, and vasodilation, suggesting collateral circulation activation. Additionally, increased optical attenuation and photoacoustic absorption in the stroke area were linked to blood-brain barrier changes. This OCT-PAM system and its quantitative analysis method offer a promising tool for early ischemic stroke diagnosis and exploring underlying molecular and cellular mechanisms.<\/jats:p>","DOI":"10.1177\/0271678x251369613","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T11:34:06Z","timestamp":1755689646000},"page":"36-50","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["OCT-PAM dual-mode imaging to evaluate early ischemic stroke in rats"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7997-3109","authenticated-orcid":false,"given":"Ning","family":"Ding","sequence":"first","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5130-2390","authenticated-orcid":false,"given":"Ben","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwen","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China"},{"name":"Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China"},{"name":"Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqian","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China"},{"name":"Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingmin","family":"Luan","sequence":"additional","affiliation":[{"name":"School of Computer and Communication Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqiu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China"},{"name":"Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China"},{"name":"Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhe","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China"},{"name":"Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70031-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61953-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308413"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0118-8"},{"key":"e_1_3_3_6_2","first-page":"399","article-title":"Executive summary: heart disease and stroke statistics \u2013 2014 update A","volume":"129","author":"Go AS","year":"2014","unstructured":"Go AS, Mozaffarian D, Roger VL, et\u00a0al. Executive summary: heart disease and stroke statistics \u2013 2014 update A. Rep Am Heart Assoc Circul 2014; 129: 399\u2013410.","journal-title":"Rep Am Heart Assoc Circul"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2019.2895779"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000049119"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60949-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490375"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010133"},{"key":"e_1_3_3_12_2","first-page":"1785","article-title":"Predicting cerebral ischemic infarct volume with diffusion and perfusion MR imaging","volume":"23","author":"Schaefer PW","year":"2002","unstructured":"Schaefer PW, Hunter GJ, He J, et\u00a0al. Predicting cerebral ischemic infarct volume with diffusion and perfusion MR imaging. Am J Neuroradiol 2002; 23: 1785\u20131794.","journal-title":"Am J Neuroradiol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-020727"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.265072"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023882"},{"key":"e_1_3_3_16_2","first-page":"226","article-title":"Comparison of multitracer PET and functional MRI in a pig MCAO model for acute ischemic stroke","volume":"6","author":"Sakoh M","year":"2001","unstructured":"Sakoh M, Ostergaard L, Gjedde A. Comparison of multitracer PET and functional MRI in a pig MCAO model for acute ischemic stroke. Keio Univ Symp Life 2001; 6: 226\u2013231.","journal-title":"Keio Univ Symp Life"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.147"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.26"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1364\/OE.15.004083"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1957169"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.001056"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.24.3.035002"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1216210"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2011.0028"},{"key":"e_1_3_3_25_2","article-title":"Non-invasive photoacoustic cerebrovascular monitoring of early-stage ischemic strokes","author":"Kim J","year":"2024","unstructured":"Kim J, Kweon JY, Choi S, et\u00a0al. Non-invasive photoacoustic cerebrovascular monitoring of early-stage ischemic strokes. In Vivo, Adv Sci 2024;","journal-title":"In Vivo, Adv Sci"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2019.100141"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41377-022-00836-2"},{"key":"e_1_3_3_28_2","article-title":"Precise ischemic stroke model inducing method with minimal tissue damage using localized photoacoustic microscopy","volume":"12828","author":"Seong D","year":"2024","unstructured":"Seong D, Han S, Kim Y, et\u00a0al. Precise ischemic stroke model inducing method with minimal tissue damage using localized photoacoustic microscopy. Pro Biomed Opt Imag 2024; 12828.","journal-title":"Pro Biomed Opt Imag"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2022.100376"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.38554"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18762636"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.7.1.015002"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-23-01617"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2024.100631"},{"key":"e_1_3_3_35_2","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie Du Sert N","year":"2020","unstructured":"Percie Du Sert N, Hurst V, Ahluwalia A, et\u00a0al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 2020; 18: e3000410.","journal-title":"PLoS Biol"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1364\/OL.458383"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1364\/AO.57.010117"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.10.1.015005"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19858532"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-024-00537-5"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0593-8"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00673-6"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170513"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687262"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110033"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.040806"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.04.005"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11793-6"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1667-0"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0512-4"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037869"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14955"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01401-0"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360404"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70264-3"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroling.2017.03.004"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290112"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1177\/0888439002250456"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2013.07.004"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050489"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.03.007"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.11.001"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15898"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231165606"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-20-821"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.2927464"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.000366"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.3512206"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.10.105004"},{"key":"e_1_3_3_70_2","article-title":"Monitoring of edema progression in permanent and transient MCAO model using SS-OCT","volume":"14","author":"Yu Y","year":"2021","unstructured":"Yu Y, Meng ZY, Li A, et\u00a0al. Monitoring of edema progression in permanent and transient MCAO model using SS-OCT. J Innov Opt Heal Sci 2021; 14.","journal-title":"J Innov Opt Heal Sci"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.6.4.045007"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.66"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0191-x"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.11.2110"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.AP.3.1.016002"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251369613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X251369613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251369613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:40Z","timestamp":1777493560000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X251369613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/0271678X251369613"],"URL":"https:\/\/doi.org\/10.1177\/0271678x251369613","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]}}}