{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:19:57Z","timestamp":1780399197600,"version":"3.54.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100018500","name":"athinoula a. martinos center for biomedical imaging, massachusetts general hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018500","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Massachusetts Life Sciences Center's Novel Therapeutics Delivery program"},{"name":"Acquisition of the Mediso PET\/CT scanner"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    Preclinical PET studies offer the opportunity to elucidate molecular mechanisms underlying early neurodevelopment with minimal invasiveness. We demonstrated the feasibility of fetal brain PET in four pregnant rats (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200942 fetuses). [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG uptake in rat fetuses was readily visualized by PET imaging. Additionally, in vivo fetal brain [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG concentration (standardized uptake value (SUV)) was significantly correlated with ex vivo SUV from matched post-mortem brains (\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.90,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). We further investigated the effect of the dopamine receptor antagonist haloperidol on cerebral glucose metabolism (CMR\n                    <jats:sub>glu<\/jats:sub>\n                    ) and [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride binding in maternal and fetal brains. Dopamine D2 receptor blockade by haloperidol resulted in significant decreases (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200933 vs 9 fetuses) in in vivo CMR\n                    <jats:sub>glu<\/jats:sub>\n                    and ex vivo [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG SUV. Consistently, haloperidol pretreatment significantly decreased [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride SUV ratio (SUVR) by 17% (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096 vs 6 fetuses) in the fetal whole-brain, using the maternal cerebellum as the reference region. In all, our results show that PET\/CT imaging of the fetal rat brain can reliably quantify specific molecular targets in vivo, and future translational studies of neurodevelopment are feasible in this model.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251370861","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T09:54:48Z","timestamp":1757325288000},"page":"586-594","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["PET\/CT imaging of the late-gestation fetal brain in pregnant rats: A proof-of-concept study"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1096-6753","authenticated-orcid":false,"given":"Torben D","family":"Pearson","sequence":"first","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bricault","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA"},{"name":"McLean Imaging Center, McLean Hospital, Belmont, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hyeon","family":"Yoo","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-8489","authenticated-orcid":false,"given":"Hsiao-Ying","family":"Wey","sequence":"additional","affiliation":[{"name":"Athinoula A. 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Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates. J Nucl Med 2005; 46: 312\u2013320.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909585107"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-05825-6"},{"key":"e_1_3_3_10_2","article-title":"Preclinical PET imaging of the developing fetus during pregnancy: current state and future potential","volume":"2025","author":"Pearson TD","year":"2025","unstructured":"Pearson TD, Bricault S, Lin YS, et al. Preclinical PET imaging of the developing fetus during pregnancy: current state and future potential. 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