{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:20:05Z","timestamp":1790688005279,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100018367","name":"swedish foundation for ms research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Training and Clinical Research"},{"DOI":"10.13039\/501100011898","name":"Marianne and Marcus Wallenberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011898","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Swedish Society for Medical Research"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    The PET radioligand [\n                    <jats:sup>11<\/jats:sup>\n                    C]L-deprenyl-D2 binds to monoamine oxidase B (MAO-B), enabling studies of neuroinflammation in various neurological disorders. This study aimed to evaluate non-invasive and parametric methods for quantifying [\n                    <jats:sup>11<\/jats:sup>\n                    C]L-deprenyl-D2 PET. Twenty-eight subjects underwent 60\u2009min dynamic [\n                    <jats:sup>11<\/jats:sup>\n                    C]L-deprenyl-D2 PET. The irreversible binding parameter \u03bb\n                    <jats:italic toggle=\"yes\">\n                      k\n                      <jats:sub>3<\/jats:sub>\n                    <\/jats:italic>\n                    and the net influx rate relative to the non-displaceable volume of distribution\n                    <jats:italic toggle=\"yes\">\n                      K\n                      <jats:sub>ND<\/jats:sub>\n                    <\/jats:italic>\n                    were estimated with an irreversible two-tissue plasma-input compartment model (2T3k). Non-invasive quantification of\n                    <jats:italic toggle=\"yes\">\n                      K\n                      <jats:sub>ND<\/jats:sub>\n                    <\/jats:italic>\n                    was performed using cerebellum corrected for specific binding with previously suggested corrections as reference tissue. These corrections were further optimised by comparison to the 2T3k non-displaceable signal in cerebellum. Parametric images were computed using a basis function implementation of the 2T3k model, reference Patlak methods and the reduced reference tissue model. Additionally, a semi-quantitative specific binding index (SBI) was calculated as the ratio of the mean activity concentration at 30\u201340 or 50\u201360\u2009min p.i. in target tissues to the peak cerebellum uptake. Parametric \u03bb\n                    <jats:italic toggle=\"yes\">\n                      k\n                      <jats:sub>3<\/jats:sub>\n                    <\/jats:italic>\n                    images agreed well with VOI-based nonlinear regression. Modified cerebellar reference models and SBI demonstrated poor-to-moderate correlations with arterial input-based analysis and yielded false positive differences in voxel-wise group comparisons. Full kinetic analysis with arterial input is required for accurate assessment of MAO-B activity with [\n                    <jats:sup>11<\/jats:sup>\n                    C]L-deprenyl-D2.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251384264","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:10:22Z","timestamp":1768633822000},"page":"1605-1615","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-invasive modelling and parametric methods for quantification of MAO-B activity using [\n                    <sup>11<\/sup>\n                    C]L-deprenyl-D2 PET"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0454-8811","authenticated-orcid":false,"given":"Karolina","family":"Hedman","sequence":"first","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"},{"name":"Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3259-2613","authenticated-orcid":false,"given":"My","family":"Jonasson","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"},{"name":"Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieuwe","family":"Appel","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"},{"name":"Medical Imaging Centre, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-8821","authenticated-orcid":false,"given":"Andreas","family":"Tolf","sequence":"additional","affiliation":[{"name":"Translational Neurology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden"},{"name":"Department of Neurology, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-1806","authenticated-orcid":false,"given":"Joachim","family":"Burman","sequence":"additional","affiliation":[{"name":"Translational Neurology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden"},{"name":"Department of Neurology, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8324-7399","authenticated-orcid":false,"given":"Mark","family":"Lubberink","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"},{"name":"Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.057"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.53"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.10.013"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440080208"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-813X(03)00102-5"},{"key":"e_1_3_3_7_2","first-page":"393","article-title":"Some puzzling pharmacological effects of monoamine oxidase inhibitors","volume":"5","author":"Knoll J","year":"1972","unstructured":"Knoll J, Magyar K. 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