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Functional interactions between CB1R and mu-opioid receptors (MOR) in analgesia have been reported. This study investigated CB1R occupancy and neuronal activation in non-human primate brains following acute administration of a CB1R agonist (CP55,940), an antagonist\/inverse-agonist (rimonabant), an MOR agonist (morphine) using simultaneous positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). [\n                    <jats:sup>11<\/jats:sup>\n                    C]OMAR, a CB1R-selective radiotracer, PET scans were acquired using bolus or bolus-plus-infusion protocols. Rimonabant (1, 3\u2009mg\/kg,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20091 for each) reduced [\n                    <jats:sup>11<\/jats:sup>\n                    C]OMAR non-displaceable binding potential by 25%\u201340% in CB1R-rich regions. To our knowledge, this is the first in vivo demonstration of CB1R occupancy by the agonist CP55,940 (0.05\u2009mg\/kg,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20092), which displaced 15%\u201330% of [\n                    <jats:sup>11<\/jats:sup>\n                    C]OMAR volume of distribution (V\n                    <jats:sub>T<\/jats:sub>\n                    ) in CB1R-rich regions. Although there was no clear dose\u2013response relationship, CP55,940 increased cerebral blood volume (CBV), whereas rimonabant caused a biphasic response. Morphine administration (1\u2009mg\/kg,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20092) reduced CBV in MOR-rich areas and modestly increased [\n                    <jats:sup>11<\/jats:sup>\n                    C]OMAR V\n                    <jats:sub>T<\/jats:sub>\n                    , suggesting a potential indirect modulation of CB1R availability. Given the small sample size and variability close to test\u2013retest levels, these preliminary findings should be interpreted with caution.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251389042","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:07:54Z","timestamp":1762236474000},"page":"882-895","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cannabinoid 1 receptor occupancy and neurovascular responses induced by agonist, antagonist\/inverse-agonist and potential modulator in non-human primate brains: PET\/fMRI study"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5234-4583","authenticated-orcid":false,"given":"Chi-Hyeon","family":"Yoo","sequence":"first","affiliation":[{"name":"Athinoula A. 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