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To elucidate the underlying biological substrates, we leveraged two-photon fluorescence microscopy resonant scanning and our recently developed deep-learning based pipeline to evaluate the cerebrovascular network in the subacute stage following three intact-skull cortical impacts in adult mice under low isoflurane. Microvascular volume density increased by 19.1\u2009\u00b1\u200918.6% after moderate impacts, while mean capillary diameters increased by 5.6\u2009\u00b1\u20093.2% for mild and by 1.1\u2009\u00b1\u20092.6% for moderate impact series; consistent with network remodeling and tone dysregulation, which limits cerebrovascular reserve. Mild impacts cohort showed a paradoxical hypercapnia response with decreases in red blood cell velocities (vRBC) (\u221220\u2009\u00b1\u200913%) in the majority (62%) of cortical penetrating arteries and a net ipsicontusional hypercapnia-induced arteriolar vRBC decrease, in stark contrast to the physiologically normal increase seen in sham mice (+27\u2009\u00b1\u200915%). Downstream, the mild impacts resulted in attenuation of hypercapnia-induced cortical capillaries\u2019 flow increase while the moderate impacts cohort showed no ipsicontusional capillary flow response. 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