{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:56:38Z","timestamp":1784948198018,"version":"3.55.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Previous PET studies with [\n 18<\/jats:sup>\n F]FCWAY were modeled with a 120-min kinetic analysis, using arterial input function with corrections for uptake of the metabolite [\n 18<\/jats:sup>\n F]fluorocyclohexanecarboxylic acid ([\n 18<\/jats:sup>\n F]FC) and vascular activity. We evaluated whether logistically less demanding analysis approaches can be used as alternatives to the full analysis. Dynamic frames were acquired for 120-min in 13 temporal lobe epilepsy (TLE) patients and 10 controls, and modeled with a simplified 3-parameter 2-tissue compartment. The gold standard binding index was\n BP<\/jats:italic>\n F<\/jats:sub>\n . Images were also generated with a 90-min (\n BP<\/jats:italic>\n F_90<\/jats:sub>\n ) and 60-min (\n BP<\/jats:italic>\n F_60<\/jats:sub>\n ) data analysis interval, without correction for [\n 18<\/jats:sup>\n F]FC (\n BP<\/jats:italic>\n F_NOFC<\/jats:sub>\n ) and without neither [\n 18<\/jats:sup>\n F]FC correction nor vascular correction (\n BP<\/jats:italic>\n ND_NOFCVA<\/jats:sub>\n ).\n \n f\n P<\/jats:sub>\n <\/jats:italic>\n was significantly higher in patients than in controls.\n BP<\/jats:italic>\n F_NOFC<\/jats:sub>\n had very similar statistical power as\n BP<\/jats:italic>\n F<\/jats:sub>\n , except in the raphe where the effect size of\n BP<\/jats:italic>\n F_NOFC<\/jats:sub>\n was about 40% lower than that of\n BP<\/jats:italic>\n F<\/jats:sub>\n .\n BP<\/jats:italic>\n ND_NOFCVA<\/jats:sub>\n had poorest performance. Negligible loss of statistical significance in detected differences occurred in the cortex with both\n BP<\/jats:italic>\n F_90<\/jats:sub>\n and\n BP<\/jats:italic>\n F_60<\/jats:sub>\n , but\n BP<\/jats:italic>\n F_60<\/jats:sub>\n was associated with some time instability in the raphe. PET scans can be reduced to 90-min in future, arterial line-based, TLE studies. Lack of correction for [\n 18<\/jats:sup>\n F]FC mildly reduced the statistical power only in the raphe.\n <\/jats:p>","DOI":"10.1177\/0271678x251400245","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T05:55:18Z","timestamp":1765173318000},"page":"1162-1174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantification of 5-HT\n 1a<\/sub>\n receptors in temporal lobe epilepsy with PET and [\n 18<\/sup>\n F]FCWAY: Effect of modeling methods on group discrimination"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2133-7951","authenticated-orcid":false,"given":"Giampiero","family":"Giovacchini","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department, Sant\u2019Andrea Hospital, La Spezia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T","family":"Toczek","sequence":"additional","affiliation":[{"name":"Clinical Epilepsy Section, National Institute of Neurological Diseases and Strokes, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Lang","sequence":"additional","affiliation":[{"name":"PET Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H","family":"Theodore","sequence":"additional","affiliation":[{"name":"Clinical Epilepsy Section, National Institute of Neurological Diseases and Strokes, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"347","volume-title":"Positron emission tomography and autoradiography: principles and applications for the brain and heart","author":"Carson RE.","year":"1986","unstructured":"Carson RE. 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