{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:19:57Z","timestamp":1780399197629,"version":"3.54.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    Extracellular vesicles (EVs) have emerged as critical mediators of cell-to-cell communication. More recently, a subset of these vesicles has been found to contain mitochondria (EV-Mito). These mitochondria-bearing EVs may act as non-cell-autonomous signaling entities and serve as potential biomarkers for injury and recovery in central nervous system (CNS) pathophysiology. Mitochondria play a vital role in regulating cellular respiration, metabolism, and overall tissue function. In the context of CNS injury or disease, mitochondrial dysfunction can disrupt metabolic homeostasis, leading to cell death and inflammation. Consequently, restoring mitochondrial function represents a key therapeutic target with strong translational potential. This special issue of\n                    <jats:italic toggle=\"yes\">JCBFM<\/jats:italic>\n                    presents a multidisciplinary collection of high-impact reviews and original research articles. These contributions cover a broad spectrum\u2014from basic studies on EV-mediated mechanisms in CNS disorders and the molecular pathways underlying intercellular mitochondrial transfer, to therapeutic applications of EVs and mitochondrial transplantation in cellular and animal models. The issue also highlights the latest clinical trial developments assessing the feasibility of EV and mitochondrial transplantation in cerebral ischemia. Collectively, these articles offer valuable insights into emerging research directions and underscore the many unresolved questions that remain\u2014particularly regarding the quantitative thresholds required for treatment efficacy and the molecular mechanisms driving beneficial tissue remodeling.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251400466","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T05:21:23Z","timestamp":1765171283000},"page":"167-170","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Editorial to the special issue on extracellular vesicles and mitochondria in CNS function and disease"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-2413","authenticated-orcid":false,"given":"Kazuhide","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-3152","authenticated-orcid":false,"given":"Dirk M","family":"Hermann","sequence":"additional","affiliation":[{"name":"Dementia and Ageing Research, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00763-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00694-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.09.009"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad332"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.11.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1704286"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav8521"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028012"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001166"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9472"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18928"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1404651111"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21984-w"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X251325039"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X251348816"},{"key":"e_1_3_2_17_2","article-title":"Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke","author":"Miyauchi Y","unstructured":"Miyauchi Y, Miyamoto N, Inaba T, et al. Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke. J Cereb Blood Flow Metab. Epub ahead of print 25 August 2025. DOI: 10.1177\/0271678X251369219.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.170"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw9128"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.08.011"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07754.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201940"},{"key":"e_1_3_2_23_2","article-title":"Mitochondrial unfolded protein response (UPR(mt)) as novel therapeutic targets for neurological disorders","author":"Chen X","unstructured":"Chen X, An H, He J, et al. Mitochondrial unfolded protein response (UPR(mt)) as novel therapeutic targets for neurological disorders. J Cereb Blood Flow Metab. Epub ahead of print 15 May 2025. DOI: 10.1177\/0271678X251341293.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01200-x"},{"key":"e_1_3_2_25_2","article-title":"Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging","author":"Velmurugan GV","unstructured":"Velmurugan GV, Vekaria HJ, Patel SP, et al. Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging. J Cereb Blood Flow Metab. Epub ahead of print 12 December 2025. DOI: 10.1177\/0271678X241306054.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_26_2","article-title":"Mitochondria transfer for myelin repair","author":"Mozafari S","unstructured":"Mozafari S, Peruzzotti-Jametti L, Pluchino S. Mitochondria transfer for myelin repair. J Cereb Blood Flow Metab. Epub ahead of print 13 March 2025. DOI: 10.1177\/0271678X251325805.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_27_2","article-title":"Molecular and cellular mechanisms of mitochondria transfer in models of central nervous system disease","author":"Nakano T","unstructured":"Nakano T, Irie K, Matsuo K, et al. Molecular and cellular mechanisms of mitochondria transfer in models of central nervous system disease. J Cereb Blood Flow Metab. Epub ahead of print 14 November 2024. DOI: 10.1177\/0271678X241300223.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_28_2","article-title":"Extracellular vesicle-mediated mitochondria delivery: Premise and promise","author":"Manickam DS","unstructured":"Manickam DS, Pinky PP, Khare P. Extracellular vesicle-mediated mitochondria delivery: Premise and promise. J Cereb Blood Flow Metab.Epub ahead of print 11 June 2025. DOI: 10.1177\/0271678X251349304.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_29_2","article-title":"Therapeutic mitochondria treatment amplifies macrophage-mediated phagocytosis and recycling exocytosis","author":"Tanaka M","unstructured":"Tanaka M, Ishikane S, Back DB, et al. Therapeutic mitochondria treatment amplifies macrophage-mediated phagocytosis and recycling exocytosis. J Cereb Blood Flow Metab. Epub ahead of print 13 March 2025. DOI: 10.1177\/0271678X251326871.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_30_2","article-title":"Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review","author":"Walker M","unstructured":"Walker M, Levitt MR, Federico EM, et al. Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review. J Cereb Blood Flow Metab. Epub ahead of print 4 December 2024. DOI: 10.1177\/0271678X241305230.","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251400466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X251400466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X251400466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:55:32Z","timestamp":1780397732000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X251400466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/0271678X251400466"],"URL":"https:\/\/doi.org\/10.1177\/0271678x251400466","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,7]]}}}