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Neonates with TGA and a ventricular septal defect (TGA-VSD,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 11) or an intact ventricular septum (TGA-IVS,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 19) and postmenstrual age-matched healthy controls (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 19) underwent bedside optical neuromonitoring within 72 h post-surgery and 72 h post-birth, respectively. Indices of cerebral blood flow (CBF\n                    <jats:sub>i<\/jats:sub>\n                    ) and oxygen delivery (CDO\n                    <jats:sub>2i<\/jats:sub>\n                    ) were derived from neuromonitoring signals. 2-year neurodevelopmental outcome was evaluated using the Bayley Scales of Infant and Toddler Development 3rd\/4th Ed. Neonates with TGA had lower CDO\n                    <jats:sub>2i<\/jats:sub>\n                    than controls. In children with TGA, lower postoperative CBF\n                    <jats:sub>i<\/jats:sub>\n                    and CDO\n                    <jats:sub>2i<\/jats:sub>\n                    were associated with lower motor composite, receptive communication and gross motor scores. When adjusted for sex and Bayley version, associations with receptive communication were stronger. In the TGA-IVS subgroup, CBF\n                    <jats:sub>i<\/jats:sub>\n                    and CDO\n                    <jats:sub>2i<\/jats:sub>\n                    were associated with all motor scales and most of these associations were stronger when adjusted. No associations were significant in the TGA-VSD subgroup. Although the modest cohort size and exploratory nature of subgroup results, postoperative CBF\n                    <jats:sub>i<\/jats:sub>\n                    and CDO\n                    <jats:sub>2i<\/jats:sub>\n                    may act as early biomarkers of brain maturity and future neurodevelopmental risk in children with TGA.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251409018","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:21:25Z","timestamp":1770614485000},"page":"1717-1729","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative cerebral oxygen availability and neurodevelopment in children with d-transposition of the great 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