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Outcomes assessed included bAVM growth, rupture, seizures, and survival. The review adhered to PRISMA guidelines and SYRCLE\u2019s protocol for animal studies. A search on PubMed and Embase was conducted (April 19, 2023; updated October 24, 2024). Exclusion criteria were; (1) Not an original, peer-reviewed full length research article, (2) not an in vivo study, (3) no bAVM induction, (4) no appropriate control group, (5) no histological or anatomical assessment during the bAVM follow-up, (6) outcome of the bAVM not reported. Meta analyses were planned for all key parameters. Risk of bias and image duplication assessments were conducted. Forty-one studies could be included in this SR. Models primarily involved mice and targeted mutations in MAPK, TGFbeta and Notch related signaling. Study designs varied significantly, limiting meta-analysis and direct comparison. We often noted high risk of bias in studies\u2019 reporting. 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