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Our dataset expands existing cerebral vascular transcriptomic profiles and reveals that\n                    <jats:italic toggle=\"yes\">Lama4<\/jats:italic>\n                    <jats:sup>\n                      <jats:sup>\n                        <jats:italic toggle=\"yes\">\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                    <\/jats:sup>\n                    endothelial cells exhibit increased arterial marker expression and reduced postcapillary venule identity. In vitro and in vivo studies indicated that compensatory upregulation of laminin \u03b15 in\n                    <jats:italic toggle=\"yes\">Lama4<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                    <\/jats:sup>\n                    vessels enhances expression of junctional proteins (\n                    <jats:italic toggle=\"yes\">Ocln<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Cldn5<\/jats:italic>\n                    ) and promotes vessel contractility via increased expression of contractile molecules in mural cells. Additionally, loss of\n                    <jats:italic toggle=\"yes\">Lama4<\/jats:italic>\n                    upregulated expression of large artery markers (\n                    <jats:italic toggle=\"yes\">Gja4<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Dll4<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Tgfb2<\/jats:italic>\n                    ) and resulted in elevated autotaxin (\n                    <jats:italic toggle=\"yes\">Enpp2<\/jats:italic>\n                    ) levels, a key enzyme in lysophosphatidic acid production implicated in stroke. Accordingly,\n                    <jats:italic toggle=\"yes\">Lama4<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                    <\/jats:sup>\n                    mice exhibited worsened stroke outcomes, driven not by immune infiltration or junctional defects, but by increased vascular permeability likely mediated by autotaxin and\/or activation of resident myeloid cells. Our data suggest that laminin \u03b14\/\u03b15 ratios in vascular BMs affect functional zonation between arterioles, capillaries and postcapillary venules by modulating metabolic pathways in endothelial and mural cells, and indirectly influencing resident myeloid cells.\n                  <\/jats:p>","DOI":"10.1177\/0271678x251410040","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:57:20Z","timestamp":1771243040000},"page":"1589-1604","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Vascular basement membrane laminins modulate functional zonation of cerebral microvessels"],"prefix":"10.1177","volume":"46","author":[{"given":"Tushar","family":"Deshpande","sequence":"first","affiliation":[{"name":"Institute of Physiological Chemistry and Pathobiochemistry, Cells in Motion Interfaculty Centre (CiMIC), University of Muenster, Muenster, 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University of Muenster, Muenster, Germany"},{"name":"Max Planck Institute for Biological Intelligence, Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Kiran","family":"Samawar","sequence":"additional","affiliation":[{"name":"Institute of Physiological Chemistry and Pathobiochemistry, Cells in Motion Interfaculty Centre (CiMIC), University of Muenster, Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7707-8503","authenticated-orcid":false,"given":"Devika Rag","family":"Thulichery","sequence":"additional","affiliation":[{"name":"Institute of Physiological Chemistry and Pathobiochemistry, Cells in Motion Interfaculty Centre (CiMIC), University of Muenster, Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigmund","family":"Budny","sequence":"additional","affiliation":[{"name":"Institute of Physiological Chemistry and Pathobiochemistry, Cells in 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