{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:07:45Z","timestamp":1789463265981,"version":"build-2803163510"},"reference-count":51,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"S\u00f6derstr\u00f6mK\u00f6nig Foundation"},{"DOI":"10.13039\/501100007687","name":"svenska l\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Government\u2013County Councils Agreement","award":["20190429"],"award-info":[{"award-number":["20190429"]}]},{"DOI":"10.13039\/501100003186","name":"fredrik och ingrid thurings stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004047","name":"karolinska institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Strategic Research Area Neuroscience"},{"DOI":"10.13039\/501100007308","name":"sveriges l\u00e4karf\u00f6rbund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007308","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Stockholm"},{"DOI":"10.13039\/100004325","name":"astrazeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    While Positron Emission Tomography (PET) images with the 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptor specific radioligand [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 show pronounced uptake in the pituitary region, and experimental studies support 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptor involvement in pituitary hormonal release, this uptake remains unquantified. In the present study we applied invasive and non-invasive models to evaluate pituitary 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptor binding. Ten subjects underwent PET with [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369, of which six participated in three additional PET-examinations after pretreatment with increasing doses of the 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptor antagonist AZD3783. While [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 binding in the brain displayed dose-dependent reductions after AZD3783, no dose-dependent inhibition of binding was observed for the pituitary. Distribution volume ratios were plotted against occupancy values to graphically estimate regional differences in non-displaceable binding, thereby allowing for estimation of\n                    <jats:italic toggle=\"yes\">BP<\/jats:italic>\n                    <jats:sub>ND<\/jats:sub>\n                    in extracerebral regions. Using this method, baseline pituitary\n                    <jats:italic toggle=\"yes\">BP<\/jats:italic>\n                    <jats:sub>ND<\/jats:sub>\n                    appears to be negligible, implying that most of the pituitary [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 uptake is comprised of free or nonspecifically bound radioligand. Our findings highlight potential pitfalls when assuming that conspicuous regional radioligand uptake indicates presence of specific binding.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261417194","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:08:51Z","timestamp":1770613731000},"page":"1730-1738","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantification of pituitary 5-HT\n                    <sub>1B<\/sub>\n                    receptors with positron emission tomography: Negligible specific binding despite conspicuous uptake"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-8514","authenticated-orcid":false,"given":"Martin","family":"G\u00e4rde","sequence":"first","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Varn\u00e4s","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-3936","authenticated-orcid":false,"given":"Johan","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-4913","authenticated-orcid":false,"given":"Jonas","family":"Svensson","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Farde","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Granville J","family":"Matheson","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8495-8125","authenticated-orcid":false,"given":"Mikael","family":"Tiger","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-4872-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00198-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90696-Z"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-018-0691-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.6.747"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00139-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0034"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051052"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881112472560"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.55"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.195"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.07.001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3476-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.174433"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2165-z"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.06.002"},{"key":"e_1_3_3_18_2","volume-title":"Medical physiology, 2e Updated Edition E-Book: with STUDENT CONSULT Online Access","author":"Boron WF","year":"2012","unstructured":"Boron WF, Boulpaep EL. Medical physiology, 2e Updated Edition E-Book: with STUDENT CONSULT Online Access. Philadelphia, PA; Elsevier Health Sciences, 2012."},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.02.063"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04307yel"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712001617"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2529-1"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.09.040"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2016.04.016"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2260-3"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20035"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116143"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01376-w"},{"issue":"12","key":"e_1_3_3_29_2","first-page":"1","article-title":"MRI evaluation of size and shape of normal pituitary gland: age and sex related changes","volume":"11","author":"Yadav P","year":"2017","unstructured":"Yadav P, Singhal S, Chauhan S, et al. MRI evaluation of size and shape of normal pituitary gland: age and sex related changes. J Clin Diagn Res 2017; 11(12): 1\u20134.","journal-title":"J Clin Diagn Res"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.98"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688699550041340"},{"key":"e_1_3_3_32_2","article-title":"Regional neurohypophyseal blood flow and its control in adult sheep","volume":"241","author":"Page RB","year":"1981","unstructured":"Page RB, Funsch DJ, Brennan RW, et al. Regional neurohypophyseal blood flow and its control in adult sheep. Am J Physiol 1981; 241: R36\u2013R43.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.1.27"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.202"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-017-0314-z"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0066"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.050583"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-020-00664-8"},{"key":"e_1_3_3_39_2","unstructured":"R Core Team. R: a language and environment for statistical computing https:\/\/www.R-project.org\/ (accessed 28 October 2022)."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-014-0064-0"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.219972"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16020-1"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3209-0"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12558"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20950486"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00187-1"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02823-2"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-025-07612-5"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24224190"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199910000-00013"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20258"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3535"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261417194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X261417194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261417194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:08:10Z","timestamp":1789459690000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X261417194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/0271678X261417194"],"URL":"https:\/\/doi.org\/10.1177\/0271678x261417194","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,8]]}}}