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In this study, we evaluated the potential of early-phase [\n                    <jats:sup>18<\/jats:sup>\n                    F]florbetaben (FBB) PET as a functional proxy for [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG\u2013PET in preclinical Alzheimer\u2019s disease models by examining regional perfusion and glucose metabolism in two transgenic mouse lines. Ninety-two APPPS1 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200917), APP\n                    <jats:sup>SAA<\/jats:sup>\n                    (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200956), and age- and sex-matched wild-type mice (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200919; 3\u201312\u2009months, 40% female) underwent static [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG\u2013PET (30\u201360\u2009min p.i.) and dynamic [\n                    <jats:sup>18<\/jats:sup>\n                    F]FBB\u2013PET (0\u201360\u2009min p.i.). Standardized uptake values were derived for both [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG\u2013PET and [\n                    <jats:sup>18<\/jats:sup>\n                    F]FBB\u2013PET for the whole brain and 14\u2009Ma\u2013Benveniste\u2013Mirrione atlas regions. We identified the 1\u20133\u2009min p.i. time window as optimal, yielding the highest concordance with [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG (\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    \u2009=\u20090.53,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) across all regions. Both APPPS1 and APP\n                    <jats:sup>SAA<\/jats:sup>\n                    mice exhibited significant increases in perfusion (both\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and glucose metabolism (APPPS1:\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.0028; APP\n                    <jats:sup>SAA<\/jats:sup>\n                    :\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) compared to wild-type controls. These findings demonstrate that early-phase [\n                    <jats:sup>18<\/jats:sup>\n                    F]FBB\u2013PET not only mirrors [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG\u2013PET-derived metabolic changes but also enables a single-scan assessment of \u03b2-amyloid pathology and brain function, thereby reducing the number of required scans and potentially the number of animals per study, and strengthening the translational value of preclinical PET research.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261420082","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:45:26Z","timestamp":1773218726000},"page":"1930-1939","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of early-phase [\n                    <sup>18<\/sup>\n                    F]florbetaben images as a proxy for brain metabolism in mouse models of Alzheimer\u2019s disease"],"prefix":"10.1177","volume":"46","author":[{"given":"Robin","family":"Gr\u00f6ger","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie L","family":"Englert","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manvir","family":"Lalia","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis","family":"de Weerd","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, 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