{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:40:35Z","timestamp":1793302835314,"version":"4.5.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    We investigate whether common circle of Willis (CoW) variants relate to cerebral blood flow (CBF) characteristics among aging adults. Vanderbilt Memory and Aging Project participants free of clinical stroke (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009390, 71\u2009\u00b1\u20098\u2009years, 55% male) completed magnetic resonance angiography to assess cerebral artery variants and pseudocontinuous arterial spin labeling to quantify resting CBF and spatial coefficient of variation (sCoV), a marker of perfusion heterogeneity or stability. Linear regression models related categorical variants to regional CBF and sCoV, adjusting for age, sex, race\/ethnicity, education, cognitive status, Framingham Stroke Risk Profile, and\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    -\u03b54 status. Absence of at least one posterior communicating artery (PcoA) related to lower occipital lobe CBF (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001) and higher global (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003), temporal (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001), and occipital lobe sCoV (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01). Bilateral PcoA absence related to lower global (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01), parietal (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01), and occipital lobe CBF (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.0001) and higher global (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), temporal (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), and occipital lobe sCoV (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.0003). Hypoplastic and fetal-type variants did not relate to outcomes (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.22). Findings demonstrate that missing PcoAs influence both perfusion magnitude and efficiency, suggesting that common CoW variants may produce regionally coherent hemodynamic effects in heart-healthy aging adults and represent markers of early cerebrovascular vulnerability.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261424053","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:32:11Z","timestamp":1773307931000},"page":"1953-1966","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Posterior communicating artery variation is linked to compromised cerebral hemodynamics in middle-aged and older adults"],"prefix":"10.1177","volume":"46","author":[{"given":"Francis E","family":"Cambronero","sequence":"first","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University School of Medicine, Nashville, TN, USA"},{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University School of Medicine, Nashville, TN, USA"},{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Hudson","family":"Robb","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University School of Medicine, Nashville, TN, USA"},{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University School of Medicine, Nashville, TN, USA"},{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly R","family":"Pechman","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University School of Medicine, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Bryan","family":"Jackson","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University School of Medicine, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjana","family":"Shashikumar","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University School of Medicine, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey 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