{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:49:47Z","timestamp":1790632187750,"version":"4.1.0"},"reference-count":60,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Austrian Science Fund","award":["10.55776\/KLI1006,10.55776\/KLI1151 and 10.55776\/PAT5436523"],"award-info":[{"award-number":["10.55776\/KLI1006,10.55776\/KLI1151 and 10.55776\/PAT5436523"]}]},{"DOI":"10.13039\/501100001822","name":"\u00f6sterreichische akademie der wissenschaften","doi-asserted-by":"publisher","award":["DOC Fellowship: 27221"],"award-info":[{"award-number":["DOC Fellowship: 27221"]}],"id":[{"id":"10.13039\/501100001822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"abstract":"<jats:p>\n                    Recent advances in functional PET (fPET) enable modeling of metabolic processes with second-level temporal resolution, opening applications such as imaging molecular connectivity comparable to fMRI. However, high-temporal fPET is more noise-sensitive, making meaningful signal extraction challenging. We developed a component-based preprocessing method adapted from fMRI, which models structured noise with tissue-specific regressors and removes low-frequency uptake trends (CompCor). This approach was applied to 20 high-temporal [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG\u2013fPET scans from a long-axial PET\/CT system (1\u2009s frames) and 16 scans from a PET\/MR scanner (3\u2009s frames). Filtering methods were compared across frequency bands, and their effects on metabolic connectivity (M-MC) assessed. Connectivity was strongly influenced by filter strategy and scanner type. CompCor produced more consistent, structured networks than standard bandpass filters. Intermediate frequency bands (0.01\u20130.1\u2009Hz) gave the most reliable connectivity across PET\/CT and PET\/MR (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.89), while high-sensitivity PET\/CT also revealed structured patterns at 0.1\u20130.2\u2009Hz. Compared to fMRI, fPET networks appeared more spatially cohesive but less differentiated. In sum, high-temporal [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG\u2013fPET enables high within-scan reliability estimation of resting-state M-MC when paired with appropriate denoising, opening a new avenue in molecular imaging. Scanner characteristics and preprocessing critically affect signal quality, while our physiologically informed pipeline improves comparability across systems and studies.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261431043","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:26:51Z","timestamp":1773404811000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["High-temporal resolution metabolic connectivity resolved by component-based noise correction"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-608X","authenticated-orcid":false,"given":"Murray B","family":"Reed","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Murga\u0161","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-2181","authenticated-orcid":false,"given":"Benjamin","family":"Eggerstorfer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-0744","authenticated-orcid":false,"given":"Christian","family":"Milz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo R","family":"Silberbauer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-3499","authenticated-orcid":false,"given":"Pia","family":"Falb","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4311-4031","authenticated-orcid":false,"given":"Elisa","family":"Briem","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, 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Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-6608","authenticated-orcid":false,"given":"Sebastian","family":"Klug","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Nics","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godber M","family":"Godbersen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical 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