{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T08:05:06Z","timestamp":1789286706839,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005725","name":"chdi foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Deficits in the synaptic vesicle protein 2A (SV2A) have been reported in various neurodegenerative diseases including Alzheimer\u2019s and Huntington\u2019s disease (HD). SV2A levels can be investigated using positron emission tomography (PET) radioligands such as [\n                    <jats:sup>11<\/jats:sup>\n                    C]UCB-J, [\n                    <jats:sup>18<\/jats:sup>\n                    F]UCB-J, and [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1. To compare the\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    performance of the PET radioligands [\n                    <jats:sup>18<\/jats:sup>\n                    F]UCB-J and [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1 in terms of brain penetration, binding profile, and SV2A quantification, we here report a head-to-head study in a mouse model of HD. Dynamic \u00b5PET\/CT scans (60\u2009min) were acquired in 17-month-old heterozygous (HET,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200920) zQ175DN and wild-type (WT,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200919) mice. Brain time-activity curves and image-derived input function were extracted and kinetic modeling was performed using Logan and the two-tissue compartmental model (2TCM). Intra-animal comparison between both radioligands revealed significantly higher\n                    <jats:italic toggle=\"yes\">\n                      K\n                      <jats:sub>1<\/jats:sub>\n                    <\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01) but equal\n                    <jats:italic toggle=\"yes\">k<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    for [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1 compared to [\n                    <jats:sup>18<\/jats:sup>\n                    F]UCB-J.\n                    <jats:italic toggle=\"yes\">V<\/jats:italic>\n                    <jats:sub>T(IDIF)<\/jats:sub>\n                    (Logan) quantification found significantly higher values for [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1 compared to [\n                    <jats:sup>18<\/jats:sup>\n                    F]UCB-J regardless of genotype (e.g. striatum WT: 22.4\u2009\u00b1\u20092.7 vs 18.6\u2009\u00b1\u20091.8\u2009mL\/cm\n                    <jats:sup>3<\/jats:sup>\n                    ). Regional analyses comparing the average\n                    <jats:italic toggle=\"yes\">V<\/jats:italic>\n                    <jats:sub>T(IDIF)<\/jats:sub>\n                    between genotypes showed no significant differences; however, voxel-based\n                    <jats:italic toggle=\"yes\">V<\/jats:italic>\n                    <jats:sub>T(IDIF)<\/jats:sub>\n                    analyses revealed significant SV2A alterations in several subregions of the brain for both radioligands. Overall, [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1 and [\n                    <jats:sup>18<\/jats:sup>\n                    F]UCB-J showed agreement across analyses, demonstrating the equal applicability of both radioligands for SV2A PET imaging.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261435323","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:38:37Z","timestamp":1776663517000},"page":"2327-2338","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing kinetic profiles of SV2A radiotracers [\n                    <sup>18<\/sup>\n                    F]SynVesT-1 and [\n                    <sup>18<\/sup>\n                    F]UCB-J using PET imaging in mice"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-1609","authenticated-orcid":false,"given":"Liesbeth","family":"Everix","sequence":"first","affiliation":[{"name":"Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium"},{"name":"\u00b5Neuro Center for Excellence, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-015X","authenticated-orcid":false,"given":"Alan","family":"Miranda","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium"},{"name":"\u00b5Neuro Center for Excellence, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1533-9504","authenticated-orcid":false,"given":"Jordy","family":"Akkermans","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium"},{"name":"\u00b5Neuro Center for Excellence, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-5117","authenticated-orcid":false,"given":"Vinod","family":"Khetarpal","sequence":"additional","affiliation":[{"name":"CHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-0196","authenticated-orcid":false,"given":"Longbin","family":"Liu","sequence":"additional","affiliation":[{"name":"CHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-1361","authenticated-orcid":false,"given":"Jonathan","family":"Bard","sequence":"additional","affiliation":[{"name":"CHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Staelens","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium"},{"name":"\u00b5Neuro Center for Excellence, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-5432","authenticated-orcid":false,"given":"Daniele","family":"Bertoglio","sequence":"additional","affiliation":[{"name":"\u00b5Neuro Center for Excellence, University of Antwerp, Antwerp, Belgium"},{"name":"Bio-Imaging Lab, University of Antwerp, Wilrijk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24343"},{"issue":"4","key":"e_1_3_3_3_2","first-page":"15","article-title":"Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging","volume":"50","author":"Howes O","year":"2024","unstructured":"Howes O, Marcinkowska J, Turkheimer FE, et al. Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging. 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