{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:46:46Z","timestamp":1785930406795,"version":"3.56.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Neonatal hypoxic\u2013ischemic encephalopathy (HIE) is a leading cause of infant mortality and long-term neurological disability. Current treatments offer limited efficacy, especially in premature or severely affected infants. The pathology of HIE involves a cascade of cellular damage initiated by oxygen and nutrient deprivation, followed by reperfusion injury characterized by excessive reactive oxygen species (ROS) production and mitochondrial dysfunction. Cardiolipin (CL), a mitochondria-specific phospholipid, plays a critical role in maintaining mitochondrial integrity, dynamics, and quality control through mitophagy and programmed cell death. In this study, we examined changes in CL subspecies in an in vitro ischemia\/reperfusion model and small and large animal models of neonatal HIE. We observed a significant increase in the ratio of monolysocardiolipin (MLCL) to CL and significant increase in saturated CL species following injury. Genetic ablation of Tafazzin protein using conditional\n                    <jats:italic toggle=\"yes\">Taz<\/jats:italic>\n                    knockout mice resulted in accumulation of MLCL and demonstrated larger brain infarct size following HIE in mice, but without affecting mitochondrial respiration or mitochondrial dynamics under basal conditions. These findings suggest that CL remodeling and MLCL accumulation contribute to the progression of neonatal HIE pathology. This study highlights an underexplored mechanism linking cardiolipin remodeling to brain injury severity, offering potential therapeutic targets for neonatal HIE.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261435368","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:25:18Z","timestamp":1774959918000},"page":"2138-2152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-species evidence for cardiolipin remodeling in neonatal hypoxic\u2013ischemic encephalopathy"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-6450","authenticated-orcid":false,"given":"Katlynn J","family":"Emaus","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett M","family":"Fogo","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Raghunayakula","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Gruley","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"McCracken","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dubs","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reagan L","family":"Speas","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J","family":"Torres Torres","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M","family":"Wider","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"},{"name":"The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-8164","authenticated-orcid":false,"given":"Thomas H","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA"},{"name":"The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60549-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309639"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1670-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.687246"},{"key":"e_1_3_3_6_2","first-page":"79","article-title":"Neonatal brain injury as a consequence of insufficient cerebral oxygenation","volume":"37","author":"Placha K","year":"2016","unstructured":"Placha K, Luptakova D, Baciak L, et al. Neonatal brain injury as a consequence of insufficient cerebral oxygenation. Neuro Endocrinol Lett 2016; 37: 79\u201396.","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.10.086"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0020151"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.070"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.04.007"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003636"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3415-17.2018"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2021.01.006"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01399-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.09.004"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201808131"},{"key":"e_1_3_3_17_2","first-page":"16","article-title":"Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry","volume":"2025","author":"Emaus KJ","year":"2025","unstructured":"Emaus KJ, et al. Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry. Front Physiol 2025; 2025: 16.","journal-title":"Front Physiol"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04745-7"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318223b910"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000523990"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b01838"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac5011876"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.07.022"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400313R"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hest.2020.09.001"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03752-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84528-8"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.112390"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx180"},{"key":"e_1_3_3_31_2","volume-title":"Handbook of superconductivity: fundamentals and materials, volume one","author":"Cardwell DA","year":"2022","unstructured":"Cardwell DA, Larbalestier DC, Aleksander BI. Handbook of superconductivity: fundamentals and materials, volume one. Boca Raton, FL: CRC Press, 2022."},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2024.103025"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.10.032"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.03.004"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.022731"},{"key":"e_1_3_3_36_2","first-page":"100076","article-title":"Dietary linoleic acid supplementation fails to rescue established cardiomyopathy in Barth syndrome","volume":"8","author":"Zhu S","year":"2024","unstructured":"Zhu S, et al. Dietary linoleic acid supplementation fails to rescue established cardiomyopathy in Barth syndrome. J Mol Cell Cardiol Plus 2024; 8: 100076.","journal-title":"J Mol Cell Cardiol Plus"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20190932"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.008289"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.97677"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21168"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.204"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1023984"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00309342"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13840"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200551200"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2013.10.012"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep01263"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja310577u"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00762857"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)45391-9"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)69888-1"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.525733"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931905"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.783068"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2439"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201511044"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261435368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X261435368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261435368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:17:28Z","timestamp":1785928648000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X261435368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/0271678X261435368"],"URL":"https:\/\/doi.org\/10.1177\/0271678x261435368","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}