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The current study investigated whether CO\n                    <jats:sub>2<\/jats:sub>\n                    -induced low frequency hemodynamic oscillations during magnetic resonance imaging would increase clearance of proteins (glial fibrillary acidic protein, neurofilament light chain, ptau217, and brain-derived tau) from brain to blood, and temporarily improve cognitive performance in individuals with chronic traumatic brain injury (TBI) and age\/sex-matched healthy controls. Results indicated that cerebrovascular reactivity, normalized CSF volume, and predicted brain age significantly differed between chronic TBI and controls, while bulk CSF flow differed only at trend levels. Multiple protein concentrations were significantly increased at ~45 min post-hypercapnia, decreased at ~90 min, and returned to pre-hypercapnia levels by ~150 min. Protein efflux was more strongly associated with total CSF volume and total white matter volume rather than cerebrovascular reactivity or bulk CSF flow. Both groups exhibited reduced cognitive interference post-hypercapnia, and hypercapnia associated symptoms quickly returned to baseline levels. In conclusion, hypercapnia temporarily increases clearance of multiple neural abundant proteins into blood, and this effect is moderated by atrophy. Current results suggest that hypercapnia may therapeutically combat pathological protein aggregation post-trauma, and prophylactically during normal aging.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261453862","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T12:09:57Z","timestamp":1779970197000},"page":"2711-2724","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Oscillating hypercapnia induces neural abundant protein efflux and potential depletion in health and chronic traumatic brain injury"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-5609","authenticated-orcid":false,"given":"Andrew R","family":"Mayer","sequence":"first","affiliation":[{"name":"The Mind Research Network\/Lovelace Biomedical Research Institute, Pete &amp; Nancy Domenici Hall, Albuquerque, NM, USA"},{"name":"Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA"},{"name":"Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA"},{"name":"Psychology Department, University of New Mexico School of Medicine, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey V","family":"Wick","sequence":"additional","affiliation":[{"name":"The Mind Research Network\/Lovelace Biomedical Research Institute, Pete &amp; 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