{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:06:14Z","timestamp":1789477574930,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["R01AG076692 and R01AG087407"],"award-info":[{"award-number":["R01AG076692 and R01AG087407"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canon Medical Systems","award":["35938"],"award-info":[{"award-number":["35938"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Cerebrospinal fluid (CSF) transport along meningeal pathways contributes to brain fluid homeostasis and is thought to change with aging, yet quantitative, region-resolved measurements across lifespan remain limited. We hypothesized that meningeal CSF transport dynamics exhibit region-specific age associations rather than uniform decline. We applied non-contrast time-spatial labeling inversion pulse (Time-SLIP) MRI combined with a bi-component analytical model to characterize CSF transport dynamics in a healthy, activity-controlled cohort of 64 adults aged 19\u201386\u2009years. Signal increase ratio time courses were decomposed into a fast Gaussian bulk-displacement and a slower \u0393-variate perfusion-like component. Linear mixed-effects models were used to assess regional and age-related effects. Model fits were robust across all participants (\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.97). CSF transport metrics differed significantly across parasagittal dura subregions and the superior sagittal sinus. Age associations were heterogeneous: the perfusion-like component declined with age in upper parasagittal dura, increased in lower parasagittal regions, and remained relatively stable within the superior sagittal sinus. Additional timing and amplitude parameters exhibited region-specific age trajectories. These findings demonstrate regionally heterogeneous aging effects on meningeal CSF transport dynamics and suggest age-related redistribution rather than uniform decline, providing a noninvasive framework for assessing physiological remodeling of CSF transport with aging.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261455452","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:07:11Z","timestamp":1780297631000},"page":"2251-2260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Meningeal CSF transport varies across parasagittal dura subregions with age in humans"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-1457","authenticated-orcid":false,"given":"Vadim","family":"Malis","sequence":"first","affiliation":[{"name":"Department of Radiology, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Na","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California San Diego, La Jolla, CA, USA"},{"name":"Department of Radiology, Korea University Guro Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Kuwatsuru","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California San Diego, La Jolla, CA, USA"},{"name":"Department of Radiology, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won C","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsue","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24271"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa179"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.14884"},{"key":"e_1_3_3_7_2","article-title":"Evaluation of CSF leaks: high-resolution CT compared with contrast-enhanced CT and radionuclide cisternography","volume":"20","author":"Stone JA","year":"1999","unstructured":"Stone JA, Castillo M, Neelon B, et al. Evaluation of CSF leaks: high-resolution CT compared with contrast-enhanced CT and radionuclide cisternography. AJNR Am J Neuroradiol 1999; 20: 706\u201312.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx191"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.178.2.1987610"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4124"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-017-0617-z"},{"key":"e_1_3_3_12_2","article-title":"Glymphatic dysfunction assessed by DTI\u2013ALPS index predicts early cognitive impairment in acute subcortical infarcts: a prospective clinical cohort study","volume":"16","author":"Wang Y","year":"2025","unstructured":"Wang Y, Yang M, Zeng X, et al. Glymphatic dysfunction assessed by DTI\u2013ALPS index predicts early cognitive impairment in acute subcortical infarcts: a prospective clinical cohort study. Front Neurol 2025; 16: 1605889.","journal-title":"Front Neurol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2492071985"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-10-36"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4030"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.mp.2022-0117"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.mp.2023-0005"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1706942114"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01176"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1812-4"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1625-15.2015"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59045-9"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(74)90099-5"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0126-9"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121537"},{"key":"e_1_3_3_26_2","first-page":"4556","volume-title":"Proceedings of the 33rd annual ISMRM meeting","author":"Malis V","year":"2025","unstructured":"Malis V, Miyazaki M. Modeling CSF outflow: a bi-component approach with Time-SLIP MRI. 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