{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T08:05:05Z","timestamp":1789286705643,"version":"build-2803163510"},"reference-count":62,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001505","name":"health research council of new zealand","doi-asserted-by":"publisher","award":["18\/225"],"award-info":[{"award-number":["18\/225"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Many infants with mild hypoxic\u2013ischemic encephalopathy (HIE) are treated with therapeutic hypothermia despite the lack of robust preclinical and clinical data that hypothermia is safe and effective. The aim of this study was to determine if hypothermia is neuroprotective after mild hypoxia\u2013ischemia (HI). Chronically instrumented near-term fetal sheep (0.85 gestation) were randomized to sham control (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20098) or to HI induced by 10\u2009min of bilateral carotid artery occlusion followed by normothermia (HI-normothermia,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20098) or 72\u2009h of hypothermia started 6\u2009h after the end of HI (HI-hypothermia,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20098) and recovered for 7\u2009days. Mild HI was associated with reduced electroencephalographic power compared with sham controls until 78\u2009h after HI. HI was associated with a loss of neurons and an increase in microglia within the hippocampus, while HI-hypothermia restored numbers of neurons and microglia back to sham control. There was no difference in the number of total oligodendrocytes between groups. HI-hypothermia was associated with a significant decrease in mature oligodendrocyte number and myelin basic protein area fraction compared with sham control, despite no change in HI-normothermia. Hypothermia for 72\u2009h is significantly neuroprotective within the hippocampus but potentially delays white matter maturation when started 6\u2009h after mild HI.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261456876","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:45:21Z","timestamp":1780307121000},"page":"2447-2460","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotection with delayed maturation of oligodendrocytes after therapeutic hypothermia for mild cerebral ischemia in near-term fetal sheep"],"prefix":"10.1177","volume":"46","author":[{"given":"Alice","family":"McDouall","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Wassink","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-6840","authenticated-orcid":false,"given":"Kelly Q","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simerdeep K","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemima","family":"Jordaan","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Battin","sequence":"additional","affiliation":[{"name":"Newborn Services, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bennet","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-7035","authenticated-orcid":false,"given":"Alistair J","family":"Gunn","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-4258","authenticated-orcid":false,"given":"Joanne O","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.317963"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2017.164"},{"key":"e_1_3_2_4_2","first-page":"442","article-title":"Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18\u201322 months","volume":"85","author":"Chalak LF","year":"2019","unstructured":"Chalak LF, Nguyen KA, Prempunpong C, et al. 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