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This PRISMA-compliant systematic review and meta-analysis aims to combine data from these studies to determine GOT\u2019s therapeutic potential in ischemic stroke, focusing on the effects on lesion size and neurofunctional deficit. After screening results from searches in PubMed and Web of Science, and citation chasing, 12 eligible studies were included. Range of evidence met nine out of 13 STAIR criteria. Median (Q1, Q3) quality score was 8.5 (6, 11.25) on the CAMARADES 15-item checklist. Both endogenous GOT up-regulation and exogenous GOT administration reduced infarct size, with SMD\u2009=\u20091.14 (95% CI 0.61\u20131.67;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), to a higher extent in mice than in rats. GOT interventions also improved edema, neuronal death, somatosensory evoked responses and neurofunctional score. The findings support the therapeutic potential of GOT for acute stroke. However, effect sizes were substantially reduced after publication bias correction (28% reduction for infarct size, with some functional outcomes losing significance), and the complete absence of female, aged, and comorbid animals limits clinical translation. High-quality, pre-registered studies in clinically relevant populations are essential before clinical trials.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261462771","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:07:16Z","timestamp":1781251636000},"page":"3007-3020","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebroprotective effects of glutamate\u2013oxaloacetate transaminase enzyme in ischemic stroke: Systematic review and meta-analysis of preclinical studies"],"prefix":"10.1177","volume":"46","author":[{"given":"Antonio","family":"Dopico-L\u00f3pez","sequence":"first","affiliation":[{"name":"Translational Stroke Laboratory Group (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikahela A","family":"L\u00f3pez-Morales","sequence":"additional","affiliation":[{"name":"Unidad Mixta de Investigaci\u00f3n Cerebrovascular, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"},{"name":"Departamento de Fisioterapia, Universidad de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda C","family":"Burguete","sequence":"additional","affiliation":[{"name":"Unidad Mixta de Investigaci\u00f3n Cerebrovascular, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"},{"name":"Departamento de Fisiolog\u00eda, Universidad de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"L\u00f3pez-Arias","sequence":"additional","affiliation":[{"name":"Translational Stroke Laboratory Group (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Correa-Paz","sequence":"additional","affiliation":[{"name":"Neurology and Cerebrovascular Disease Group, Neurological Sciences and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Centre, Neuroscience Area La Paz Institute for Health Research (idiPAZ), La Paz University Hospital, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"P\u00e9rez-Mato","sequence":"additional","affiliation":[{"name":"Translational Stroke Laboratory Group (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Morales-Caba","sequence":"additional","affiliation":[{"name":"Unidad Mixta de Investigaci\u00f3n Cerebrovascular, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"},{"name":"Unidad de Ictus, Servicio de Neurolog\u00eda, Hospital Universitario y Polit\u00e9cnico La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-6101","authenticated-orcid":false,"given":"Juan B","family":"Salom","sequence":"additional","affiliation":[{"name":"Unidad Mixta de Investigaci\u00f3n Cerebrovascular, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"},{"name":"Departamento de Fisiolog\u00eda, Universidad de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-1039","authenticated-orcid":false,"given":"Francisco","family":"Campos","sequence":"additional","affiliation":[{"name":"Translational Stroke Laboratory Group (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00369-7"},{"key":"e_1_3_2_3_2","article-title":"2026 Guideline for the early management of patients with acute ischemic stroke: a guideline from the American Heart Association\/American Stroke Association","volume":"57","author":"Prabhakaran S","year":"2026","unstructured":"Prabhakaran S, Gonzalez NR, Zachrison KS, et al. 2026 Guideline for the early management of patients with acute ischemic stroke: a guideline from the American Heart Association\/American Stroke Association. 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