{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:53:45Z","timestamp":1791014025159,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"canadian institutes of health research","doi-asserted-by":"publisher","award":["PJT169049"],"award-info":[{"award-number":["PJT169049"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New Frontiers in Research Fund \u2013 Transformation","award":["GR026425\/GR027195"],"award-info":[{"award-number":["GR026425\/GR027195"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Tropomyosin receptor kinases family members TrkA, TrkB, and TrkC mediate critical processes, such as neuronal growth, survival, and synaptic plasticity, and have been implicated in neuropsychiatric disorders. In this work, we characterized the pharmacokinetics of the novel positron emission tomography (PET) radioligand [\n                    <jats:sup>18<\/jats:sup>\n                    F]TRACK for in vivo quantification of TrkB\/C in the human brain. Seven healthy volunteers (three men; 20\u201361\u2009years) underwent a 90\u2009min PET scan following an intravenous bolus injection of [\n                    <jats:sup>18<\/jats:sup>\n                    F]TRACK. Arterial blood sampling was performed throughout image acquisition. [\n                    <jats:sup>18<\/jats:sup>\n                    F]TRACK was slowly metabolized, accounting for 60% of the plasma activity at 90\u2009min, with two more polar radiometabolites observed. Regional time-activity curves (TACs) showed moderate uptake (SUV: 1\u20132) and good reversibility in gray matter regions. Across regions, the two-tissue compartment model (2TCM) yielded superior fits than the 1TCM for 98% of extra-striatal gray-matter TACs, whereas it improved fits for only 52% of striatal TACs. Total distribution volume (\n                    <jats:italic toggle=\"yes\">V<\/jats:italic>\n                    <jats:sub>T<\/jats:sub>\n                    ) ranged from 2.49\u2009\u00b1\u20090.30\u2009ml\/cm\n                    <jats:sup>3<\/jats:sup>\n                    (thalamus) to 1.94\u2009\u00b1\u20090.21\u2009ml\/cm\n                    <jats:sup>3<\/jats:sup>\n                    (hippocampus) showing good identifiability (%SE: 1%\u20135%) and low inter-subject variability (%CoV &lt;14%). Transient equilibrium between [\n                    <jats:sup>18<\/jats:sup>\n                    F]TRACK in tissue and plasma was reached at approximately 70\u2009min. Shortening the scan duration to 60\u2009min preserved\n                    <jats:italic toggle=\"yes\">V<\/jats:italic>\n                    <jats:sub>T<\/jats:sub>\n                    accuracy and precision.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261463956","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:43:07Z","timestamp":1781869387000},"page":"2783-2793","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Kinetic modeling of the tropomyosin receptor kinases radioligand [\n                    <sup>18<\/sup>\n                    F]TRACK in human brain with high-resolution positron emission tomography"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-6179","authenticated-orcid":false,"given":"Christian","family":"Ramos-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Clinical and Translational Sciences Lab, Douglas Research Centre, Montreal, QC, Canada"},{"name":"Department of Psychiatry, Douglas Research Centre, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kankana","family":"Nisha Aji","sequence":"additional","affiliation":[{"name":"Clinical and Translational Sciences Lab, Douglas Research Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2062-3516","authenticated-orcid":false,"given":"Chris","family":"Hung-Hsin Hsiao","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-765X","authenticated-orcid":false,"given":"Vladimir","family":"Grouza","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-5872","authenticated-orcid":false,"given":"Robert","family":"Hopewell","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Jaworski","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2259-9627","authenticated-orcid":false,"given":"Gassan","family":"Massarweh","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-1259","authenticated-orcid":false,"given":"Jean-Paul","family":"Soucy","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-578X","authenticated-orcid":false,"given":"Daniel","family":"Chartrand","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"},{"name":"Department of Anesthesia, Montreal Neurological Institute, McGill University, Montreal, QC, 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