{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T16:25:57Z","timestamp":1793982357130,"version":"4.8.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Canadian Institutes for Health Research to S.D.","award":["PJT-469654, PJT-159778"],"award-info":[{"award-number":["PJT-469654, PJT-159778"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>\n                    Understanding cerebral metabolism is an essential undertaking to address brain health and tackle ambiguities in associated neurodegenerative diseases. Despite the abundance of detailed observational findings on specific functionalities of metabolism, there remains a gap in holistic understanding that could provide a suitable predictive framework, and hence be put to clinical use. Computational models can support such wider goals. Accordingly, we performed a scoping review of computational models on human cerebral glucose metabolism on the PubMed database. We selected 15 models on which we conducted a qualitative assessment of\n                    <jats:italic toggle=\"yes\">Verification<\/jats:italic>\n                    based on reproducibility and internal validity;\n                    <jats:italic toggle=\"yes\">Validation<\/jats:italic>\n                    for computational and biological relevance, sensitivity analysis and external validity; and\n                    <jats:italic toggle=\"yes\">Evaluation<\/jats:italic>\n                    , where we inquired whether the model increased domain knowledge, with the capacity to be extended for improved generalizability. We raised critical shortcomings, including overall poor reproducibility, lack of internal and external validity, and certain unclear metabolic assumptions that compromised biological relevance. We proposed that for a computational model to improve its applicability such as predicting metabolic state through the human lifespan, Verification, Validation and Evaluation (VV&amp;E) issues raised should be addressed, which would facilitate the involvement of disciplines beyond mathematics.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261465840","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:30:37Z","timestamp":1782304237000},"page":"3043-3058","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A scoping review of computational models on human glucose cerebral metabolism"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-0876","authenticated-orcid":false,"given":"Parissa","family":"Fereydouni-Forouzandeh","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Laval University, Qu\u00e9bec City, QC, Canada"},{"name":"Quebec Heart and Lung Research Institute, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-8307","authenticated-orcid":false,"given":"Andr\u00e9anne","family":"Michaud","sequence":"additional","affiliation":[{"name":"School of Nutrition, Laval University, Qu\u00e9bec City, QC, Canada"},{"name":"Centre Nutrition, Sant\u00e9 et Soci\u00e9t\u00e9 (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Doyon","sequence":"additional","affiliation":[{"name":"Quebec Heart and Lung Research Institute, Qu\u00e9bec City, QC, Canada"},{"name":"Department of Mathematics and Statistics, Laval University, Qu\u00e9bec City, QC, Canada"},{"name":"CERVO Brain Research Centre, Quebec Mental Health Institute, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-0745","authenticated-orcid":false,"given":"Simon","family":"Duchesne","sequence":"additional","affiliation":[{"name":"Quebec Heart and Lung Research Institute, Qu\u00e9bec City, QC, Canada"},{"name":"Department of Radiology and Nuclear Medicine, Laval University, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-012-9305-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-009062-7.50026-6"},{"key":"e_1_3_3_4_2","first-page":"1843","volume-title":"Handbook of physiology\u2014neurophysiology","author":"Sokoloff L.","year":"1960","unstructured":"Sokoloff L. The metabolism of the central nervous system in vivo. In: Field J, Magoun HW, Hall VE (eds.) Handbook of physiology\u2014neurophysiology, vol. 3. Washington, DC: American Physiological Society, 1960, pp.1843\u20131864."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.3.731"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/npre.2008.1856.1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073627"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.08.019"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.07.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010459107"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10625"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.06.021"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.128"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10785"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12999"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00053"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmb.2005.49403304246"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10110450"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.011"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.04.200"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.4.632"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-5-13"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073785"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200600098"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201400277"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5947"},{"key":"e_1_3_3_27_2","unstructured":"Thota S Akbar A. 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