{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:12Z","timestamp":1792787652468,"version":"4.5.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Royal Society of New Zealand Te Ap\u0101rangi Marsden Fund","award":["19-UOA-170"],"award-info":[{"award-number":["19-UOA-170"]}],"id":[{"id":"https:\/\/ror.org\/04tajb587","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Atrial fibrillation (AF) is associated with a high risk of stroke, as well as cognitive decline and dementia. Advanced imaging techniques were employed to test the hypothesis that AF worsens cerebrovascular function as evaluated using neurovascular coupling (NVC) and cerebrovascular carbon dioxide reactivity (CVR\n                    <jats:sub>CO2<\/jats:sub>\n                    ) tests. Twenty healthy controls (HC; 63.4\u2009\u00b1\u20099.5\u2009years) and 19 AF patients (66.6\u2009\u00b1\u200912.0\u2009years) completed NVC (visual stimulation with a flickering checkerboard) and CVR\n                    <jats:sub>CO2<\/jats:sub>\n                    (5%CO\n                    <jats:sub>2<\/jats:sub>\n                    ) assessments during functional (blood oxygen level-dependent [BOLD]) and perfusion (arterial spin labelling) magnetic resonance imaging. Additionally, brain volumes and cognition were assessed. During CVR\n                    <jats:sub>CO2<\/jats:sub>\n                    assessment, neither %\u2206 in BOLD signal (HC: 3.09\u2009\u00b1\u20090.50; AF: 3.23\u2009\u00b1\u20090.70%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.513) nor %\u2206 in cerebral blood flow (CBF) (HC: 36.6\u2009\u00b1\u200918.8; AF: 43.6\u2009\u00b1\u200920.6%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.319) were different between groups. During NVC assessment, CMRO\n                    <jats:sub>2<\/jats:sub>\n                    (HC: 5.25\u2009\u00b1\u20091.84; AF: 4.36\u2009\u00b1\u20092.50%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.285), %\u2206BOLD (HC: 1.60\u2009\u00b1\u20090.38; AF: 1.66\u2009\u00b1\u20090.79%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.762) and %\u2206CBF (HC: 49.4 [20.1\u201371.9]; AF: 51.7 [38.3\u201366.9]%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.850) all increased similarly in HC and AF. AF patients had lower hippocampal volume relative to total intracranial volume than HC (0.50\u2009\u00b1\u20090.06 vs 0.55\u2009\u00b1\u20090.06%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.020). There were no differences between HC and AF in cognitive performance across multiple domains (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). These results suggest that NVC and CVR\n                    <jats:sub>CO2<\/jats:sub>\n                    responses are preserved in AF.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261465842","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:21:01Z","timestamp":1782386461000},"page":"2822-2836","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-modal magnetic resonance imaging to assess cerebrovascular function in patients with atrial fibrillation"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0348-5597","authenticated-orcid":false,"given":"Harvey J","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medical and Health Sciences, Manaaki Manawa\u2013The Centre for Heart Research, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-8861","authenticated-orcid":false,"given":"Catherine A","family":"Morgan","sequence":"additional","affiliation":[{"name":"School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand"},{"name":"Centre for Advanced MRI, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Webster","sequence":"additional","affiliation":[{"name":"Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory YH","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, Liverpool John Moores University and Liverpool Heart and Chest Hospital, University of Liverpool, Liverpool, UK"},{"name":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Dubowitz","sequence":"additional","affiliation":[{"name":"Centre for Advanced MRI, University of Auckland, Auckland, New Zealand"},{"name":"Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-9222","authenticated-orcid":false,"given":"James P","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical and Health Sciences, Manaaki Manawa\u2013The Centre for Heart Research, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"1","article-title":"Atrial fibrillation: epidemiology, screening and digital health","volume":"37","author":"Linz D","year":"2024","unstructured":"Linz D, Gawalko M, Betz K, et al. 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