{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:27:04Z","timestamp":1786796824305,"version":"build-2736575974"},"reference-count":199,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"abstract":"<jats:p>Aneurysmal subarachnoid haemorrhage (aSAH) is a catastrophic cerebrovascular event associated with high early mortality and substantial long-term disability. Delayed cerebral ischaemia (DCI) is among its most severe complications and a principal driver of secondary neurological injury. Despite decades of research describing diverse pathophysiological mechanisms, a unifying framework for DCI pathogenesis is still lacking, and its clinical prediction remains challenging. We therefore conducted a narrative review to synthesise current understanding of the spatiotemporal evolution of brain injury following aSAH, with emphasis on integrating mechanisms across overlapping clinical phases. Acute phase events from physical effects of bleeding, including intracranial pressure elevation, hyperacute vasospasm and microvascular thrombosis, sets off the evolution of downstream brain injuries. During the early phase, converging mechanisms such as neuroinflammation, oxidative stress, spreading depolarisation and blood\u2013brain barrier disruption coalesce into pan-vascular dysfunction and systemic hypercoagulability. Rather than representing a singular vasospastic complication, these processes collectively evolve into pathobiological states characterised by large-artery vasospasm, microvascular constriction, diffuse capillary occlusion and supply\u2013demand mismatch, ultimately precipitating DCI and cortical infarction. This review examines the key mechanisms underlying these aforementioned processes and aims to establish mechanistic continuity across the evolving phases of injury following aSAH.<\/jats:p>","DOI":"10.1177\/0271678x261474706","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:25:44Z","timestamp":1784953544000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Haemorrhage, hypercoagulability and ischaemia: Evolution of brain injury after aneurysmal subarachnoid haemorrhage"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2391-3599","authenticated-orcid":false,"given":"Yuyang","family":"Wang","sequence":"first","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences, University of Western Australia, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Fisker","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences, University of Western Australia, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipi","family":"Mishra","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences, University of Western Australia, Perth, WA, Australia"},{"name":"Intensive Care Unit, Sir Charles Gairdner Hospital, Nedlands, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew H","family":"Anstey","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences, University of Western Australia, Perth, WA, Australia"},{"name":"Intensive Care Unit, Sir Charles Gairdner Hospital, Nedlands, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.4.591"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-024-01237-w"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003091"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13412"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-019-00905-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-021-01136-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031015"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-022-01545-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/2021.12.FOCUS21650"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1973.39.2.0226"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-018-0674-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.3188"},{"key":"e_1_3_2_14_2","first-page":"827154","article-title":"Brain injury after transient global cerebral ischemia and subarachnoid hemorrhage","volume":"2013","author":"Sehba FA","year":"2013","unstructured":"Sehba FA, Pluta RM, Macdonald RL. Brain injury after transient global cerebral ischemia and subarachnoid hemorrhage. Stroke Res Treat 2013; 2013: 827154.","journal-title":"Stroke Res Treat"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010219"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-021-00688-y"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.56.6.0784"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1972.36.5.0537"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01809135"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164106X114991"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-023-01752-y"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-01162-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.09.011"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-015-0177-y"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-005-0025-4"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1974.40.4.0459"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15511"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.4"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.4.602"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.042799"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2013.03.036"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.1.53"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-015-0423-9"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1213-7"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","unstructured":"Asano T Sano K. Pathogenetic role of no-reflow phenomenon in experimental subarachnoid hemorrhage in dogs. Epub ahead of print 1 April 1977. DOI: 10.3171\/jns.1977.46.4.0454.","DOI":"10.3171\/jns.1977.46.4.0454"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.8.1.36"},{"key":"e_1_3_2_37_2","first-page":"199","volume-title":"Cerebral vasospasm: neurovascular events after subarachnoid hemorrhage","author":"Sehba FA","unstructured":"Sehba FA, Friedrich V. Cerebral microvasculature is an early target of subarachnoid hemorrhage. In: Zuccarello M, Clark JF, Pyne-Geithman G, et al. (eds.) Cerebral vasospasm: neurovascular events after subarachnoid hemorrhage. Vienna: Springer 2012, pp.199\u2013205."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","unstructured":"Sehba FA Mostafa G Friedrich V et al. Acute microvascular platelet aggregation after subarachnoid hemorrhage. Epub ahead of print 1 June 2005. DOI: 10.3171\/jns.2005.102.6.1094.","DOI":"10.3171\/jns.2005.102.6.1094"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12511"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.10.029"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211020865"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11223704"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.589275"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040072"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000273"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-022-01779-3"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.837650"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15033"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.63729\/TJIC.2026.687"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1721165"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-016-0354-7"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5181"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/2040-7378-4-8"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01326-w"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax7171"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10571-w"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.06.024"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-019-00710-x"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-022-00312-4"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.90.3.251"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00282"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164104X3798"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200106154203"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111899"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15070677"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25298"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03503-6"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0690-x"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025997"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2015.288"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e40562"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-0353-1_18"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.4103\/2394-8108.178541"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.3390\/futurepharmacol5040059"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217997"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00347"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00323.2002"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/972417"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00629.x"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00478"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200204000-00011"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.602532"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-161612"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.07.010"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","unstructured":"Pluta RM Boock RJ Afshar JK et al. Source and cause of endothelin-1 release into cerebrospinal fluid after subarachnoid hemorrhage. Epub ahead of print 1 August 1997. DOI: 10.3171\/jns.1997.87.2.0287.","DOI":"10.3171\/jns.1997.87.2.0287"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","unstructured":"Seifert V L\u00f6ffler B-M Zimmermann M et al. Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage. Epub ahead of print 1 January 1995. DOI: 10.3171\/jns.1995.82.1.0055.","DOI":"10.3171\/jns.1995.82.1.0055"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9508-9"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","unstructured":"Juvela S. Plasma endothelin and big endothelin concentrations and serum endothelin-converting enzyme activity following aneurysmal subarachnoid hemorrhage. Epub ahead of print 1 December 2002. DOI: 10.3171\/jns.2002.97.6.1287.","DOI":"10.3171\/jns.2002.97.6.1287"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0466-6"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01761"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90432-K"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp026"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hest.2020.08.002"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113255"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","unstructured":"Conway LW McDonald LW. Structural changes of the intradural arteries following subarachnoid hemorrhage. Epub ahead of print 1 December 1972. DOI: 10.3171\/jns.1972.37.6.0715.","DOI":"10.3171\/jns.1972.37.6.0715"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","unstructured":"Mayberg MR Okada T Bark DH. The significance of morphological changes in cerebral arteries after subarachnoid hemorrhage. Epub ahead of print 1 April 1990. DOI: 10.3171\/jns.1990.72.4.0626.","DOI":"10.3171\/jns.1990.72.4.0626"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01403606"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","unstructured":"Mayberg MR Okada T Bark DH. The role of hemoglobin in arterial narrowing after subarachnoid hemorrhage. Epub ahead of print 1 April 1990. DOI: 10.3171\/jns.1990.72.4.0634.","DOI":"10.3171\/jns.1990.72.4.0634"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000053848.06436.AB"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164106X151990"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-013-0310-1"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198612000-00007"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01138.2004"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","unstructured":"Kim P Sundt TM Vanhoutte PM. Alterations of mechanical properties in canine basilar arteries after subarachnoid hemorrhage. Epub ahead of print 1 September 1989. DOI: 10.3171\/jns.1989.71.3.0430.","DOI":"10.3171\/jns.1989.71.3.0430"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2092-6"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2025.111837"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-023-00483-8"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","unstructured":"Macdonald RL Weir BKA Young JD et al. Cytoskeletal and extracellular matrix proteins in cerebral arteries following subarachnoid hemorrhage in monkeys. Epub ahead of print 1 January 1992. DOI: 10.3171\/jns.1992.76.1.0081.","DOI":"10.3171\/jns.1992.76.1.0081"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.04.049"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059952"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.11.004"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.318237"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13806"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-024-01323-z"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.793411"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16686595"},{"key":"e_1_3_2_117_2","first-page":"819340","article-title":"Subarachnoid hemorrhage, spreading depolarizations and impaired neurovascular coupling","volume":"2013","author":"Koide M","year":"2013","unstructured":"Koide M, Sukhotinsky I, Ayata C, et al. Subarachnoid hemorrhage, spreading depolarizations and impaired neurovascular coupling. Stroke Res Treat 2013; 2013: 819340.","journal-title":"Stroke Res Treat"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.137"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.21"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab457"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01988-w"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-015-0111-3"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-024-01242-z"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.006353"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20921974"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.74"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211045446"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1730346"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS141288"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1062-z"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.04.002"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.10.035"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.09.200"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.30.309"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-025-02309-x"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-04615-6_25"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.122943"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105208"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0594-7"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00555"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.960398"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1692983"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-437772"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316886"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-08-0495"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1646319"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1752471"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2184"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)61488-2"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-11-0834"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12574"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.33393\/jcb.2023.2502"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001690"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02007-6"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1629-7"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-103"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00829-x"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231197946"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.320224"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12463"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-016-2792-6"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168444"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.06.001"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.045225"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-022-01074-9"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.047574"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1354224"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000227519.27569.45"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.06.919"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100471RR"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0575-y"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","unstructured":"Voldby B Enevoldsen EM Jensen FT. Regional CBF intraventricular pressure and cerebral metabolism in patients with ruptured intracranial aneurysms. Epub ahead of print 1 January 1985. DOI: 10.3171\/jns.1985.62.1.0048.","DOI":"10.3171\/jns.1985.62.1.0048"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2022.10.040"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.597005"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1114\/1.168"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.173"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.042936"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep22070"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.153"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008077"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.131"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25488"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7169"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17721666"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26183-1"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00850-5"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2024.109841"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.2176\/jns-nmc.2023-0201"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2009.46.2.93"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr303"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.09.016"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1970.218.4.943"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1975.tb03657.x"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412453340"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp338"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3770"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23859"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16674486"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231193661"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.17"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261474706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X261474706","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261474706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T11:58:51Z","timestamp":1786795131000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X261474706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":199,"alternative-id":["10.1177\/0271678X261474706"],"URL":"https:\/\/doi.org\/10.1177\/0271678x261474706","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"article-number":"0271678X261474706"}}