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However, despite long-standing guidelines recommending rigorous monitoring of key physiological factors, this aspect is not always incorporated into experimental designs and is generally underreported. Further, even when collected it is not always clear whether the data are integrated into the interpretation of results, potentially affecting translation. This review outlines the importance of monitoring, reporting and interpreting key physiological parameters in experimental stroke models, including the cardiovascular and respiratory systems, metabolism, temperature, circadian rhythm and intracranial pressure. 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