{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:14:15Z","timestamp":1790270055484,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The FOCAS and AURORA studies","award":["2016T86"],"award-info":[{"award-number":["2016T86"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"abstract":"<jats:p>\n                    Cerebrospinal fluid (CSF) mediated brain clearance and inflammation are known features of cerebral amyloid angiopathy (CAA), that may be affected by the cortical gyrencephalic structure. Considering these processes in the development of cerebral microbleeds (CMB), we compared sulcal and gyral cortical CMB densities in sporadic and Dutch-type hereditary CAA (sCAA and D-CAA). CMBs were annotated on 3-Tesla susceptibility weighted imaging. Sulcal and gyral cortex-maps were created using FreeSurfer\u2019s curvature analysis. Sulcal and gyral CMB densities were compared using a generalized linear mixed model. Sensitivity analyses examined sulcal versus gyral CMB densities (1) after adjusting for disease type (sCAA vs D-CAA) and (2) in participants with lobar and deep CMBs. Thirty-nine participants were included (28\/11 sCAA\/D-CAA, mean age 70\/53\u2009years). Sulcal CMB density was higher than gyral CMB density (\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    \u2009=\u20090.57, exp(\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    )\u2009=\u20091.76,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001, exp(\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    ) provides the CMB density ratio\n                    <jats:sub>(sulcal vs gyral)<\/jats:sub>\n                    ). Sensitivity analyses showed robustness of sulcal CMB predominance when taking disease type into account (\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    \u2009=\u20090.46, exp(\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    )\u2009=\u20091.59,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.036), with higher densities in sCAA (\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    \u2009=\u20091.36, exp(\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    )\u2009=\u20093.90,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.045), and when analyzing the participants with lobar and deep CMBs (\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    \u2009=\u20090.62, exp(\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    )\u2009=\u20091.86,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Sulcal CMB predominance in CAA may indicate varying hemorrhagic vulnerability along the cortex, potentially arising from anatomy-based inflammatory and CSF flow dynamics variations.\n                  <\/jats:p>","DOI":"10.1177\/0271678x261482016","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:14:47Z","timestamp":1787199287000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Following the curvature: Sulcal versus gyral cortical localization of cerebral microbleeds in cerebral amyloid angiopathy"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-0997","authenticated-orcid":false,"given":"Manon R","family":"Schipper","sequence":"first","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-9379","authenticated-orcid":false,"given":"Thijs W","family":"van Harten","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma A","family":"Koemans","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle J","family":"Goeman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke JH","family":"Wermer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-8959","authenticated-orcid":false,"given":"Matthias JP","family":"van Osch","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-229X","authenticated-orcid":false,"given":"Marianne AA","family":"van Walderveen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300503"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05277-1"},{"key":"e_1_3_3_4_2","first-page":"637","article-title":"Histopathological analysis of foci in signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds","volume":"20","author":"Fazekas F","year":"1999","unstructured":"Fazekas F, Kleinert R, Roob G, et al. Histopathological analysis of foci in signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999; 20: 637\u2013642.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.537"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep44715"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20596"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140864"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22099"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25512"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019181719"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213650"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr182"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102187"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1052-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3042"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100916"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000210084"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209647"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1330-6"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000165"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.035019"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00131-X"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000540899"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0396"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030304"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2001.0915"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1256"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.027"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.11.020"},{"key":"e_1_3_3_35_2","first-page":"586","article-title":"Engineering and algorithm design for an image processing API: a technical report on ITK\u2014the Insight Toolkit","volume":"85","author":"Yoo TS","year":"2002","unstructured":"Yoo TS, Ackerman MJ, Lorensen WE, et al. Engineering and algorithm design for an image processing API: a technical report on ITK\u2014the Insight Toolkit. Stud Health Technol Inform 2002; 85: 586\u2013592.","journal-title":"Stud Health Technol Inform"},{"key":"e_1_3_3_36_2","unstructured":"MeVisLab.de. MeVisLab documentation (Internet). https:\/\/www.mevislab.de\/developer\/documentation (2004 accessed 1 January 2025)."},{"key":"e_1_3_3_37_2","unstructured":"R Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing 2023 https:\/\/www.R-project.org\/ (accessed 1 April 2026)."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12946"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46329-1"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-022-00318-y"},{"key":"e_1_3_3_43_2","first-page":"12","article-title":"The role of cerebrospinal fluid flow in the subarachnoid space in beta-amyloid clearance","volume":"19","author":"Kim J","year":"2023","unstructured":"Kim J, Barcus RA, Lipford ME, et al. The role of cerebrospinal fluid flow in the subarachnoid space in beta-amyloid clearance. Alzheimers Dement 2023; 19: 12\u201318.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.10.014"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2020"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx191"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X21996175"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54372-1"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003181"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00114-X"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.625931"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261482016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X261482016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261482016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:48:51Z","timestamp":1790268531000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X261482016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":50,"alternative-id":["10.1177\/0271678X261482016"],"URL":"https:\/\/doi.org\/10.1177\/0271678x261482016","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"article-number":"0271678X261482016"}}