{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:55:04Z","timestamp":1792155304267,"version":"4.4.0"},"reference-count":54,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["R01NS127156 and R01NS122742"],"award-info":[{"award-number":["R01NS127156 and R01NS122742"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Gamma entrainment using sensory stimuli (GENUS) uses 40\u2009Hz-pulsed sensory stimuli to entrain neural activity in the gamma band (30\u2013150\u2009Hz). However, the effect of GENUS on low-frequency vascular oscillations has not been fully explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objective of this study is to elucidate the effect of GENUS on vasomotion in healthy mice and potential confounds for future application in disease studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Head-fixed, awake C57Bl\/6 mice (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200918; 9M and 9F) aged between 18 and 60\u2009weeks were subjected to white light of either 40\u2009Hz visual flicker (GENUS), or constant stimulus (Control). Blood flow was imaged using laser speckle contrast imaging (LSCI) before, during, immediately after 1\u2009h of stimulus, and 30\u2009min after the stimulus termination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A linear mixed-effects model showed that GENUS enhanced the magnitude of 0.2\u20130.4\u2009Hz blood flow oscillations by 38% during stimulation and by 30% at 30\u2009min after stimulation compared to Control when controlled for age, sex, and other factors. The effect on vasomotion was distributed across the surface of many cortical regions not limited to visual areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These results support the exploration of GENUS for increasing vasomotion in therapeutic contexts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0271678x261492627","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:20:42Z","timestamp":1789640442000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Visual gamma stimulation causes prolonged enhancement of low-frequency blood flow oscillations across superficial cortical regions in mice"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6545-8643","authenticated-orcid":false,"given":"Piergiulio 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