{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:31:26Z","timestamp":1793341886356,"version":"4.5.0"},"reference-count":106,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"national institute of neurological disorders and stroke","doi-asserted-by":"publisher","award":["K08NS117888, R37NS110699, R01NS084028, R01NS094692, R01NS102870 and R01NS126326"],"award-info":[{"award-number":["K08NS117888, R37NS110699, R01NS084028, R01NS094692, R01NS102870 and R01NS126326"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although advancing age is associated with worse recovery after stroke, little is known about how aging influences post-stroke reorganization of neuronal circuits and networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used wide-field calcium imaging to compare cortical network dynamics and behavioral recovery after focal photothrombotic stroke in forepaw somatosensory cortex in young (3-month-old) and aged (18-month-old) Thy1-GCaMP6f mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both young and aged mice developed significant somatomotor deficits after stroke, but only young mice exhibited substantial behavioral recovery. While young and aged mice showed differences in baseline forepaw-evoked response amplitudes and their trajectories after stroke, the temporal dynamics of these circuits were comparable both before and after stroke between young and aged mice. Relative to aged mice, young mice demonstrated superior baseline measures of hemispheric stimulus-locked fidelity, bilateral coherence, and cortical entrainment, that declined significantly after stroke; this trend was absent in aged mice. Finally, only young mice showed significant recovery of somatosensory and somatomotor functional connectivity after stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results suggest similarities in neuronal network degradation caused by aging and stroke and highlight the vulnerability of neuronal networks in both processes. Our findings also indicate a potential network-level basis for chronic deficits in stroke survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0271678x261496658","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:13Z","timestamp":1790927653000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Normal aging limits cortical network reorganization and behavioral recovery after experimental stroke"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-9584","authenticated-orcid":false,"given":"Asher J","family":"Albertson","sequence":"first","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyrillos","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose A","family":"Le\u00f3n-Alvarado","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Pati","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam Q","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3979-0906","authenticated-orcid":false,"given":"Jin-Moo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00266-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67702-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.36"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308398"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.18.2363"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115034"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000101461.61501.65"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.604090"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2023.120589"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-141110"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.2.346"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824367ab"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.33094"},{"key":"e_1_3_3_15_2","article-title":"Effects of age on long-term functional recovery in patients with stroke","volume":"56","author":"Yoo JW","year":"2020","unstructured":"Yoo JW, Hong BY, Jo L, et al. Effects of age on long-term functional recovery in patients with stroke. Medicina (Kaunas) 2020; 56: e00907.","journal-title":"Medicina (Kaunas)"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210603"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10714"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh032"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.09.077"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0808-18.2018"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218731110"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199709)27:1<57::AID-SYN6>3.0.CO;2-C"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.1.334"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep05101"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119287"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg133"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.17.1.85"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.08.059"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.02.020"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.01.077"},{"key":"e_1_3_3_31_2","first-page":"272","article-title":"Mechanisms of spontaneous recovery","volume":"63","author":"Cramer SC. Repairing the human brain after stroke: I","year":"2008","unstructured":"Cramer SC. Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery. Ann Neurol 2008; 63: 272\u2013287.","journal-title":"Ann Neurol"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1574"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858413491146"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-00396-7"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231235598"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh456"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5269.1791"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4249-08.2009"},{"key":"e_1_3_3_39_2","article-title":"Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice","volume":"12","author":"Bowen RM","year":"2025","unstructured":"Bowen RM, Lee J, Wang B, et al. Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice. Neurophotonics 2025; 12: S14604.","journal-title":"Neurophotonics"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag1328"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968311411054"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.051"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20507"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521083113"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0625-20.2020"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.11.022"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021319"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.00663"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.81"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108697"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz314"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00005-8"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2021252118"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185759"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016322"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525369113"},{"key":"e_1_3_3_57_2","volume-title":"Robust 2D Phase Unwrapping Algorithm","author":"Zhao Z.","year":"2026","unstructured":"Zhao Z. Robust 2D Phase Unwrapping Algorithm. MATLAB Central File Exchange, 2026."},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-15-58"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.08.007"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0622-08.2008"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.135"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008963"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.06.015"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1859-2"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.5.2144"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2735"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68852"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.044"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4146"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2501"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2922-12.2013"},{"key":"e_1_3_3_72_2","article-title":"Interactions between intrinsic and stimulus-evoked activity in recurrent neural networks","author":"Abbott LF","unstructured":"Abbott LF, Rajan K, Sompolinsky H. Interactions between intrinsic and stimulus-evoked activity in recurrent neural networks. arXiv preprint arXiv:09123832 2009.","journal-title":"arXiv preprint arXiv"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.018"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2022.108685"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15801"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001267"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0058-y"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.227462"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv261"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08002"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102092"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09511"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57860-0"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0752-6"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0051-18.2018"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21905"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.596155"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29751-6"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000150"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr033"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2025.108325"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-025-10981-x"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000071883.63724.A7"},{"key":"e_1_3_3_94_2","article-title":"Aged lipid-laden microglia display impaired responses to stroke","volume":"15","author":"Arbaizar-Rovirosa M","year":"2023","unstructured":"Arbaizar-Rovirosa M, Pedragosa J, Lozano JJ, et al. Aged lipid-laden microglia display impaired responses to stroke. EMBO Mole Med 2023; 15: EMMM202217175.","journal-title":"EMBO Mole Med"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1088-4"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4325"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800165115"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00252.x"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2012.01306.x"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.10.019"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.01.027"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7100929"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2377"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253050"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.070"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.90080.3"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1404109111"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261496658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X261496658","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X261496658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:46:31Z","timestamp":1793339191000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X261496658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":106,"alternative-id":["10.1177\/0271678X261496658"],"URL":"https:\/\/doi.org\/10.1177\/0271678x261496658","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"article-number":"0271678X261496658"}}