{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:53:52Z","timestamp":1791176032183,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Med Decis Making"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Purpose. To assess the impact of illicit drug use and chronic hepatitis C virus (HCV) on health-related quality of life (HRQoL) in women with HIV or at risk for HIV infection. Methods. Cross-sectional analysis of data from the Women\u2019s Interagency Health Study (WIHS) of women with HIV ( n = 2508) and at high risk of HIV infection ( n = 889) in the US. A Short-Form-6D (SF-6D) HRQoL measure derived from the Medical Outcomes Study\u2013HIV (MOS-HIV) questionnaire, HIV infection status, CD4 cell count (a measure of immune status), antiretroviral treatment, current illicit drug use (heroin and\/or cocaine), and HCV status were assessed at a recent study visit. We developed multivariate linear regression models adjusting for age, race\/ethnicity, education, and testing for interactions. Results. HIV-infected women with \u2264200 CD4 cells\/\u00b5L had lower mean HRQoL scores (0.69) than either HIV-infected women with &gt;200 CD4 cells\/\u00b5L (0.78) or HIV-uninfected women (0.80) ( P &lt; 0.01). In multivariate analysis, illicit drug use, chronic HCV, and low CD4 count were independently associated with lower HRQoL. There was a differential effect of HCV and illicit drug use for HIV-infected women depending on CD4 cell count: HIV-infected women with &gt;200 CD4 cells\/\u00b5L had a significantly greater reduction in HRQoL associated with illicit drug use (\u22120.063) and chronic HCV (\u22120.036) than women with \u2264200 CD4 cells\/\u00b5L (\u22120.017, \u22120.005 respectively). Conclusions. Poorly controlled HIV, illicit drug use, and chronic HCV are associated with lower HRQoL. Illicit drug use and chronic HCV have greater HRQoL impacts for HIV-infected women with well-controlled HIV versus those with poorly controlled HIV, which may affect clinical and policy priorities.<\/jats:p>","DOI":"10.1177\/0272989x13507340","type":"journal-article","created":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:42:06Z","timestamp":1381279326000},"page":"800-808","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Health-Related Quality of Life in HIV-Infected and At-Risk Women"],"prefix":"10.1177","volume":"34","author":[{"given":"Brandon","family":"Aden","sequence":"first","affiliation":[{"name":"Department of Public Health, Weill Cornell Medical College, New York, NY (BA, BRS)"},{"name":"British Columbia Centre for Excellence in HIV\/AIDS, Vancouver, BC, Canada (BN)"},{"name":"Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada (BN)"},{"name":"Center for Health Decision Science, Harvard School of Public Health, Boston, MA (EW)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohdan","family":"Nosyk","sequence":"additional","affiliation":[{"name":"Department of Public Health, Weill Cornell Medical College, New York, NY (BA, BRS)"},{"name":"British Columbia Centre for Excellence in HIV\/AIDS, Vancouver, BC, Canada (BN)"},{"name":"Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada (BN)"},{"name":"Center for Health Decision Science, Harvard School of Public Health, Boston, MA (EW)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Wittenberg","sequence":"additional","affiliation":[{"name":"Department of Public Health, Weill Cornell Medical College, New York, NY (BA, BRS)"},{"name":"British Columbia Centre for Excellence in HIV\/AIDS, Vancouver, BC, Canada (BN)"},{"name":"Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada (BN)"},{"name":"Center for Health Decision Science, Harvard School of Public Health, Boston, MA (EW)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Schackman","sequence":"additional","affiliation":[{"name":"Department of Public Health, Weill Cornell Medical College, New York, NY (BA, BRS)"},{"name":"British Columbia Centre for Excellence in HIV\/AIDS, Vancouver, BC, Canada (BN)"},{"name":"Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada (BN)"},{"name":"Center for Health Decision Science, Harvard School of Public Health, Boston, MA (EW)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"key":"bibr1-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X0202200103"},{"key":"bibr2-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00326.x"},{"key":"bibr3-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07332.x"},{"key":"bibr4-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03299.x"},{"key":"bibr5-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.6.1467"},{"key":"bibr6-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00216-6"},{"key":"bibr7-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908193410802"},{"key":"bibr8-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450107"},{"key":"bibr9-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1086\/339042"},{"key":"bibr10-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.12.012"},{"key":"bibr11-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2008.0005"},{"key":"bibr12-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318209754c"},{"key":"bibr13-0272989X13507340","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199803000-00004"},{"key":"bibr14-0272989X13507340","unstructured":"WIHS Cohort Information. 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