{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:54:50Z","timestamp":1791644090119,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Med Decis Making"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n Previous research suggests that physicians\u2019 inclination to refer patients for suspected cancer is a relatively stable characteristic of their decision making. We aimed to identify its psychological determinants in the presence of a risk-prediction algorithm.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We presented 200 UK general practitioners with online vignettes describing patients with possible colorectal cancer. Per the vignette, GPs indicated the likelihood of referral (from highly unlikely to highly likely) and level of cancer risk (negligible\/low\/medium\/high), received an algorithmic risk estimate, and could then revise their responses. After completing the vignettes, GPs responded to questions about their values with regard to harms and benefits of cancer referral for different stakeholders, perceived severity of errors, acceptance of false alarms, and attitudes to uncertainty. We tested whether these values and attitudes predicted their earlier referral decisions.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The algorithm significantly reduced both referral likelihood (\n b<\/jats:italic>\n = \u22120.06 [\u22120.10, \u22120.007],\n P<\/jats:italic>\n = 0.025) and risk level (\n b<\/jats:italic>\n = \u22120.14 [\u22120.17, \u22120.11],\n P<\/jats:italic>\n < 0.001). The strongest predictor of referral was the value GPs attached to patient benefits (\n b<\/jats:italic>\n = 0.30 [0.23, 0.36],\n P<\/jats:italic>\n < 0.001), followed by benefits (\n b<\/jats:italic>\n = 0.18 [0.11, 0.24],\n P<\/jats:italic>\n < 0.001) and harms (\n b<\/jats:italic>\n = \u22120.14 [\u22120.21, \u22120.08],\n P<\/jats:italic>\n < 0.001) to the health system\/society. The perceived severity of missing a cancer vis-\u00e0-vis overreferring also predicted referral (\n b<\/jats:italic>\n = 0.004 [0.001, 0.007],\n P<\/jats:italic>\n = 0.009). The algorithm did not significantly reduce the impact of these variables on referral decisions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The decision to refer patients who might have cancer can be influenced by how physicians perceive and value the potential benefits and harms of referral primarily for patients and the moral seriousness of missing a cancer vis-\u00e0-vis over-referring. These values contribute to an internal threshold for action and are important even when an algorithm informs risk judgments.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n Physicians\u2019 inclination to refer patients for suspected cancer is determined by their assessment of cancer risk but also their core values; specifically, their values in relation to the perceived benefits and harms of referrals and the seriousness of missing a cancer compared with overreferring.<\/jats:p>\n <\/jats:list-item>\n \n We observed a moral prioritization of referral decision making, in which considerations about benefits to the patient were foremost, considerations about benefits but also harms to the health system or the society were second, while considerations about oneself carried little or no weight.<\/jats:p>\n <\/jats:list-item>\n \n Having an algorithm informing assessments of risk influences referral decisions but does not remove or significantly reduce the influence of physicians\u2019 core values.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1177\/0272989x251376024","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:18:33Z","timestamp":1760620713000},"page":"88-101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Determinants of Physicians\u2019 Referrals for Suspected Cancer Given a Risk-Prediction Algorithm: Linking Signal Detection and Fuzzy Trace Theory"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-0838","authenticated-orcid":false,"given":"Olga","family":"Kostopoulou","sequence":"first","affiliation":[{"name":"Imperial College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"P\u00e1lfi","sequence":"additional","affiliation":[{"name":"Goldsmiths University of London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavleen","family":"Arora","sequence":"additional","affiliation":[{"name":"Imperial College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2851-5797","authenticated-orcid":false,"given":"Valerie","family":"Reyna","sequence":"additional","affiliation":[{"name":"Cornell University, Cornell, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30593-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp20X709433"},{"key":"e_1_3_3_4_2","volume-title":"Detection Theory: A User\u2019s Guide","author":"Macmillan N","year":"2005","unstructured":"Macmillan N, Creelman C. Detection Theory: A User\u2019s Guide. Mahwah (NJ): Lawrence Erlbaum Associates; 2005."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03207704"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X18813357"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X20936212"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-12-122"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X8200200303"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016439"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1529-1006.001"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X221105473"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1930297500002291"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-017-4099-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-021-00069-1"},{"key":"e_1_3_3_16_2","unstructured":"National Institute for Health and Care Excellence (NICE). Suspected Cancer: Recognition and Referral. Final scope. July 16 2024. Available from: https:\/\/alpha.nice.org.uk\/guidance\/GID-HTE10050\/documents\/html-to-pdf-7."},{"key":"e_1_3_3_17_2","unstructured":"Barratt H Kirwan M. Clustered data - effects on sample size and approaches to analysis. 2009. Available from: http:\/\/www.healthknowledge.org.uk\/public-health-textbook\/research-methods\/1a-epidemiology\/clustered-data."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1037\/1076-898X.12.3.179"},{"issue":"333","key":"e_1_3_3_19_2","article-title":"Attitudes to risk taking in medical decision making among British, Dutch and Belgian general practitioners","volume":"40","author":"Grol R","year":"1990","unstructured":"Grol R, Whitfield M, De Maeseneer J, Mokkink H. Attitudes to risk taking in medical decision making among British, Dutch and Belgian general practitioners. Br J Gen Pract J R Coll Gen Pract. 1990;40(333):134\u20136.","journal-title":"Br J Gen Pract J R Coll Gen Pract"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00781"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3758\/PBR.16.2.225"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ps.31.020180.001125"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11127-019-00684-6"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0275"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00215-4"},{"issue":"2","key":"e_1_3_3_26_2","article-title":"The impact of regret and worry on the threshold level of concern for flood insurance demand: evidence from Dutch homeowners","volume":"13","author":"Robinson PJ","year":"2018","unstructured":"Robinson PJ, Wouter Botzen WJ. The impact of regret and worry on the threshold level of concern for flood insurance demand: evidence from Dutch homeowners. Judgm Decis Mak. 2018;13(2):237\u201345.","journal-title":"Judgm Decis Mak"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2024-017375"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocad019"}],"container-title":["Medical Decision Making"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0272989X251376024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0272989X251376024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0272989X251376024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:03:40Z","timestamp":1777658620000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0272989X251376024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/0272989X251376024"],"URL":"https:\/\/doi.org\/10.1177\/0272989x251376024","relation":{},"ISSN":["0272-989X","1552-681X"],"issn-type":[{"value":"0272-989X","type":"print"},{"value":"1552-681X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]}}}