{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:01:16Z","timestamp":1777500076138,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffusion-weighted magnetic resonance imaging (MRI) is increasingly being used for assessing the treatment succes in oncology, but the real clinical value needs to evaluated by comparison with other, already established, metabolic imaging techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To prospectively evaluate the clinical potential of diffusion-weighted MRI with apparent diffusion coefficient (ADC) mapping for gastrointestinal stromal tumor (GIST) response to targeted therapy compared with 18F-fluorodeoxyglucose positron emission tomography\/computed tomography (18F-FDG PET\/CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Eight patients (mean age, 56 \u00b1 11 years) known to have metastatic GIST underwent 18F-FDG PET\/CT and MRI (T1Gd, DWI [b = 50,300,600], ADC mapping) simultaneously, before and after change in targeted therapy. MR and PET\/CT examinations were first analyzed blindly. Second, PET\/CT images were co-registered with T1Gd-MR images for lesion detection. Only 18F-FDG avid lesions were considered. Maximum standardized uptake value (SUV\n                      <jats:sub>max<\/jats:sub>\n                      ) and the corresponding minimum ADC\n                      <jats:sub>min<\/jats:sub>\n                      were measured for the six largest lesions per patient, if any, on baseline and follow-up examinations. The relationship between changes in SUV\n                      <jats:sub>max<\/jats:sub>\n                      and ADC\n                      <jats:sub>min<\/jats:sub>\n                      was analyzed (Spearman's correlation).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-four metastases (12 hepatic, 12 extra-hepatic) were compared on PET\/CT and MR images. SUV\n                      <jats:sub>max<\/jats:sub>\n                      decreased from 7.7 \u00b1 8.1 g\/mL to 5.5 \u00b1 5.4 g\/mL ( P = 0.20), while ADC\n                      <jats:sub>min<\/jats:sub>\n                      increased from 1.2 \u00b1 0.3 \u00d7 10\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s to 1.5 \u00b1 0.3 \u00d7 10\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s ( P = 0.0002). There was a significant association between changes in SUV\n                      <jats:sub>max<\/jats:sub>\n                      and ADC\n                      <jats:sub>min<\/jats:sub>\n                      (rho = \u2212 0.62, P = 0.0014), but not between changes in lesions size ( P = 0.40).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Changes in ADC\n                      <jats:sub>min<\/jats:sub>\n                      correlated with the response of 18F-FDG avid GIST to targeted therapy. Thus, diffusion-weighted MRI may represent a radiation-free alternative for follow-up treatment for metastatic GIST patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185113485732","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:33:27Z","timestamp":1368146007000},"page":"837-842","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Diffusion-weighted magnetic resonance imaging in metastatic gastrointestinal stromal tumor (GIST): a pilot study on the assessment of treatment response in comparison with 18F-FDG PET\/CT"],"prefix":"10.1177","volume":"54","author":[{"given":"Sabine","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Radiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Dunet","sequence":"additional","affiliation":[{"name":"Department of Nuclear 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