{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:08:33Z","timestamp":1786720113126,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parenchyma-preserving resection for the treatment of benign pancreatic neuroendocrine tumors (NETs) has been tried, and preoperative prediction of benign pancreatic NET is important. Recently, diffusion-weighted imaging (DWI) of abdomen magnetic resonance imaging (MRI) has been used to characterize benign and malignant tumors and DWI might be helpful in prediction of benign pancreatic NETs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the value of gadoxetic acid-enhanced MRI and DWI in predicting benign pancreatic NETs for determination of parenchyma-preserving resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Our ethics committee approved this study with a waiver of informed consent given its retrospective design. We searched radiology and pathology databases from November 2010 to July 2012 to identify patients who underwent surgery for pancreatic NETs (&lt;4\u2009cm). Twenty patients in the benign group and 14 patients in the non-benign group were included in this study. Two radiologists analyzed the morphologic features, signal intensity on MR images including DWI ( b\u2009=\u2009800), and dynamic enhancement pattern of the tumors with consensus. The tumor-to-parenchyma ratio and tumor apparent diffusion coefficients (ADCs) were quantitatively assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The benign pancreatic NETs were more often round (7\/20, 35%) or ovoid (13\/20, 65%) in shape and less hypovascular on the arterial phase (3\/20, 15%) than were the non-benign pancreatic NETs (1\/14, 7.1% and 5\/14, 35.8%; 7\/14, 50% respectively; P\u2009&lt;\u20090.05). Main pancreatic duct dilatation by tumors was demonstrated only in non-benign pancreatic NETs (4\/14, 28.4%; P\u2009=\u20090.021). ADC values and ratios were significantly different between benign pancreatic NETs (mean, 1.48\u2009\u00d7\u200910\n                      <jats:sup>\u22123\u2009<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/sec, 1.11\u2009\u00b1\u20090.25, each) and non-benign pancreatic NETs (mean, 1.04\u2009\u00d7\u200910\n                      <jats:sup>\u22123\u2009<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/sec, 0.74\u2009\u00b1\u20090.13, each) ( P\u2009&lt;\u20090.01). Other qualitative and quantitative analyses between benign and non-benign pancreatic NETs were not significantly different ( P\u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abdominal MRI with DWI may be useful for differentiating benign pancreatic NETs from non-benign pancreatic NETs, which might be helpful for determination of parenchyma-preserving resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185113494982","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T21:45:00Z","timestamp":1375134300000},"page":"140-148","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["The value of gadoxetic acid-enhanced and diffusion-weighted MRI for prediction of grading of pancreatic neuroendocrine tumors"],"prefix":"10.1177","volume":"55","author":[{"given":"Kyung Mi","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongil","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"bibr1-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-011-0172-2"},{"key":"bibr2-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32834c554d"},{"key":"bibr3-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1319-3"},{"key":"bibr4-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0949-8"},{"key":"bibr5-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181cf155c"},{"key":"bibr6-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0801-z"},{"key":"bibr7-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.02.022"},{"key":"bibr8-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.06.005"},{"key":"bibr9-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.9809"},{"key":"bibr10-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01198-3"},{"key":"bibr11-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2501080291"},{"key":"bibr12-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090021"},{"key":"bibr13-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1593\/neo.81328"},{"key":"bibr14-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e3181c0d772"},{"key":"bibr15-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22541"},{"key":"bibr16-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1159\/000217604"},{"key":"bibr17-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ec124e"},{"key":"bibr18-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1159\/000098012"},{"key":"bibr19-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31823cdaa0"},{"key":"bibr20-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23549"},{"key":"bibr21-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.118367"},{"key":"bibr22-0284185113494982","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0809"},{"key":"bibr23-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21340"},{"key":"bibr24-0284185113494982","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.02.017"}],"container-title":["Acta 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