{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:00:46Z","timestamp":1779894046809,"version":"3.53.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Application of dual-energy CT in characterization of adrenal nodules has not been well evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the ability of dual-energy CT scan to differentiate an adrenal adenoma from a metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Fifty-five patients presenting 63 adrenal nodules underwent dual-energy CT scan at tube voltages of 80\u2009kVp and 140\u2009kVp. Mean attenuation values were measured for every nodule at 80\/140\u2009kVp and at 40\/100\u2009keV. Mean attenuation value changes between 140\u2009kVp and 80\u2009kVp (MAVC\n                      <jats:sub>140\u201380kVp<\/jats:sub>\n                      ) and mean attenuation value changes between 100\u2009keV and 40\u2009keV (MAVC\n                      <jats:sub>100\u201340keV<\/jats:sub>\n                      ) were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 63 adrenal nodules available for analyses, 42 nodules were classified as adenoma (26 lipid-rich and 16 lipid-poor) and 21 were classified as metastases. MAVC\n                      <jats:sub>140\u201380kVp<\/jats:sub>\n                      and MAVC\n                      <jats:sub>100\u201340keV<\/jats:sub>\n                      of all adenomas (including lipid-poor and lipid-rich) were significantly higher than metastases ( P\u2009&lt;\u20090.001). According to receiver-operating characteristic (ROC) curve analyses, areas under the ROC curve of MAVC\n                      <jats:sub>140\u201380kVp<\/jats:sub>\n                      and MAVC\n                      <jats:sub>100\u201340keV<\/jats:sub>\n                      for diagnosing adrenal adenomas were both of 0.964. When the cut-off points were set at 2.42 HU and 6.95 HU for MAVC\n                      <jats:sub>140\u201380kVp<\/jats:sub>\n                      and MAVC\n                      <jats:sub>100\u201340keV<\/jats:sub>\n                      , the two parameters both had a sensitivity of 78.6% and a specificity of 100% in adenoma diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Unique energy spectrum information provided by dual-energy CT scan displays a high capacity to distinguish adrenal adenoma from metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185113501660","type":"journal-article","created":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T21:39:38Z","timestamp":1377207578000},"page":"505-512","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Dual-energy CT: clinical application in differentiating an adrenal adenoma from a metastasis"],"prefix":"10.1177","volume":"55","author":[{"given":"Jiang Wei","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, The First People\u2019s Hospital of Wujiang, Wujiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Zhi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, The First People\u2019s Hospital of Wujiang, Wujiang, PR 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