{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:35:28Z","timestamp":1777502128455,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late enhancement (LE) imaging is increasingly used for diagnosis of non-ischemic cardiomyopathy. However, the mostly patchy appearance of LE in this context may reduce the reproducibility of LE measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report intra- and inter-observer variabilities of LE measurements in Fabry disease using manual and semi-automated quantification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Twenty MRI data-sets of male patients aged 44\u2009\u00b1\u20097 years were analyzed twice (interval 12 months) by one observer and additionally once by a second observer. Left ventricular (LV) parameters were determined using cine MRI. Gradient-echo LE images were analyzed by manual planimetry and by a semi-automatic prototype software. Variabilities were determined by Bland-Altman analyses and additionally intra-class correlation coefficient (ICC) values were calculated to survey intra- and inter-observer reproducibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The amount of LE was 5.2\u2009\u00b1\u20095.1\u2009mL or 2.8\u2009\u00b1\u20092.6 % of LV mass (observer 2). LE was detected predominantly intramurally in a patchy pattern. All patients had LE restricted to the basal infero-lateral parts of the LV. The extent of LE correlated to LV mass (207\u2009\u00b1\u200970\u2009g, P\u2009&lt;\u20090.05, r\u2009=\u20090.6). The intra- and inter-observer variabilities were \u22120.6 to 1.0\u2009mL and \u22120.7 to 1.6\u2009mL, respectively (95% confidence intervals). ICC values were 0.981\u20130.999. The semi-automatic software allowed quantification of LE areas in all patients. The comparison of LE amount determined by semi-automatic software versus manual planimetry yielded an intra-observer variability ranging from \u22121.9 to 2.3\u2009mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Semi-automatic planimetry of patchy LE in patients with Fabry disease is feasible. The determined intra- and inter-observer variabilities for manual and semi-automatic planimetry were in the range of 20\u201340% of LE amount with high ICC values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185113505275","type":"journal-article","created":{"date-parts":[[2013,9,28]],"date-time":"2013-09-28T00:23:56Z","timestamp":1380327836000},"page":"155-160","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Reproducibility of manual and semi-automated late enhancement quantification in patients with Fabry disease"],"prefix":"10.1177","volume":"55","author":[{"given":"Wolfram","family":"Machann","sequence":"first","affiliation":[{"name":"Institute of Radiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Geier","sequence":"additional","affiliation":[{"name":"The Intervention Centre, Oslo University Hospital, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Koeppe","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Siemens AG Healthcare Sector, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Greiser","sequence":"additional","affiliation":[{"name":"Siemens AG Healthcare Sector, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Breunig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joern","family":"Sandstede","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietbert","family":"Hahn","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Koestler","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Center, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinrad","family":"Beer","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Center, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Department of Radiology, Medical University Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"bibr1-0284185113505275","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.4.1800981"},{"key":"bibr2-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-10-35"},{"key":"bibr3-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-008-9300-x"},{"key":"bibr4-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000062036.35852.01"},{"key":"bibr5-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.035"},{"key":"bibr6-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02602-5"},{"key":"bibr7-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118493.13323.81"},{"key":"bibr8-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00189-X"},{"key":"bibr9-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-010-9620-5"},{"key":"bibr10-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.045609"},{"key":"bibr11-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000036368.63317.1C"},{"key":"bibr12-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.020"},{"key":"bibr13-0284185113505275","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-004-5806-z"},{"key":"bibr14-0284185113505275","unstructured":"Desnick RJIY, Eng CM Scriver CRBA, Sly WS, Valle D. \u03b1 \u2013Galactosidase A deficiency: Fabry Disease, The metabolic and molecular basis of inherited disease. 8th edn. 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